In Vivo Investigation of Thiomer-Polyvinylpyrrolidon Nanoparticles Using Magnetic Resonance Imaging

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Fältnamn	Indikatorer	Metadata
000		02985naa a2200409 4500
001		oai:DiVA.org:mau-3919
003		SwePub
008		200228s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-39192 URI
024	7	a https://doi.org/10.1002/jps.219692 DOI
040		a (SwePub)mau
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Albrecht, Karin4 aut
245	1 0	a In Vivo Investigation of Thiomer-Polyvinylpyrrolidon Nanoparticles Using Magnetic Resonance Imaging
264	1	b Wiley Inter Science,c 2010
338		a print2 rdacarrier
520		a This study focused on the investigation of the permeation enhancing effects of a stomach targeted, nanoparticulate drug delivery system. The polyacrylic acid–cysteine/polyvinylpyrrolidon nanoparticles were loaded with the magnetic resonance imaging (MRI) contrast agent diethylenetriaminepentaacetic acid gadolinium( III)dihydrogen salt (Gd-DTPA). Average particle size was determined to be 130nm and the optimum for stability was found to be below a pH of 4.5. In vitro permeation studies were performed on rat gastric mucosa and revealed an eightfold increase in Gd- DTPA uptake when incorporated in the nanoparticles compared to evaluation in the presence of unformulated polyacrylic acid–cysteine. In vivo investigations with rats were performed via the noninvasive MRI method in order to track the nanoparticles way through the gastrointestinal tract. When Gd-DTPA was administered orally as nanoparticulate suspension, an increased MRI signal in the urinary bladder was detected after 34 min, providing evidence for systemic uptake and renal elimination of the contrast agent. As control experiments with Gd-DTPA only or in combination with unformulated polyacrylic acid–cysteine revealed no MRI signal increase at all, the significant permeation enhancing effect could be identified based on the nanoparticulate formulation.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
653		a nanoparticles
653		a oral drug delivery
653		a absorption enhancer
653		a polymeric drug delivery
700	1	a Greindl, Melanie4 aut
700	1	a Deutel, Britta4 aut
700	1	a Kremser, Christian4 aut
700	1	a Wolf, Christian4 aut
700	1	a Talasz, Heribert4 aut
700	1	a Stollenwerk, Maria Magdalena,d 1959-4 aut
700	1	a Debbage, Paul4 aut
700	1	a Bernkop-Schnürch, Andreas4 aut
773	0	t Journal of Pharmaceutical Sciencesd : Wiley Inter Scienceg 99:4, s. 2008-2017q 99:4<2008-2017x 0022-3549x 1520-6017
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-3919
856	4 8	u https://doi.org/10.1002/jps.21969

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Av författaren/redakt...: Albrecht, Karin; Greindl, Melanie; Deutel, Britta; Kremser, Christi ...; Wolf, Christian; Talasz, Heribert; visa fler...; Stollenwerk, Mar ...; Debbage, Paul; Bernkop-Schnürch ...; visa färre...

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