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Cross-Clade HIV-1-Specific Neutralizing IgA in Mucosal and Systemic Compartments of HIV-1-Exposed, Persistently Seronegative Subjects
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- Devito, C (författare)
- Department of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden; Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
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- Hinkula, J (författare)
- Malmö högskola,Fakulteten för hälsa och samhälle (HS),Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
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- Kaul, R (författare)
- Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
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- (creator_code:org_t)
- Lippincott Williams & Wilkins, 2002
- 2002
- Engelska.
- Ingår i: Journal of Acquired Immune Deficiency Syndromes. - : Lippincott Williams & Wilkins. - 1525-4135 .- 1944-7884. ; 30:4, s. 413-420
- Tidskriftsartikel (refereegranskat)
Abstract
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- There is an urgent need for a universally effective HIV-1 vaccine, but whether a vaccine will be able to protect against HIV-1 of different clades is a significant concern. IgA from HIV-1-exposed, persistently seronegative (HEPS) subjects has been shown to neutralize HIV-1 and to block epithelial HIV-1 transcytosis, and it may target novel HIV-1 epitopes. We have tested the ability of plasma and mucosal IgA purified from HEPS subjects to neutralize HIV-1 primary isolates of different viral clades and phenotypes. IgA from two groups of HEPS subjects was tested: sex workers from Nairobi, Kenya, where clades A and D predominate, and the heterosexual partners of individuals infected by clade B virus. HIV-1-infected and low-risk uninfected individuals were included as controls. IgA purified from the blood, genital tract, and saliva of most HEPS sex workers demonstrated significant crossclade HIV-1 neutralization, whereas a more clade-restricted pattern of neutralization was found in partners of clade B-infected individuals. IgA purified from HIV-1-infected individuals also mediated cross-clade neutralization, whereas IgA from uninfected controls lacked neutralizing activity. In conclusion, mucosal and plasma IgA from HEPS subjects neutralizes HIV-1 of different clades. This ability to induce HIV-1-specific systemic and mucosal IgA may be an important feature of an effective prophylactic HIV-1 vaccine.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
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- Devito, C
- Hinkula, J
- Kaul, R
- Kimani, J
- Kiama, P
- Lopalco, L
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- Barass, C
- Piconi, S
- Trabattoni, D
- Bwayo, JJ
- Plummer, F
- Clerici, M
- Broliden, K
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