Sökning: onr:"swepub:oai:DiVA.org:oru-111022" > All cause and cause...
Fältnamn | Indikatorer | Metadata |
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001 | oai:DiVA.org:oru-111022 | |
003 | SwePub | |
008 | 240130s2024 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:238233033 | |
009 | oai:lup.lub.lu.se:5bedb531-2142-4f7f-9957-9b6d8d35bf3d | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1110222 URI |
024 | 7 | a https://doi.org/10.1136/bmj-2023-0775642 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2382330332 URI |
024 | 7 | a https://lup.lub.lu.se/record/5bedb531-2142-4f7f-9957-9b6d8d35bf3d2 URI |
040 | a (SwePub)orud (SwePub)kid (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fernández de la Cruz, Lorenau Karolinska Institute,Karolinska Institutet4 aut |
245 | 1 0 | a All cause and cause specific mortality in obsessive-compulsive disorder :b nationwide matched cohort and sibling cohort study |
264 | 1 | b BMJ Publishing Group Ltd,c 2024 |
338 | a print2 rdacarrier | |
520 | a OBJECTIVE: To estimate the risk of all cause and cause specific mortality in people with obsessive-compulsive disorder (OCD) compared with matched unaffected people from the general population and with their unaffected siblings. DESIGN: Population based matched cohort and sibling cohort study. SETTING: Register linkage in Sweden.PARTICIPANTS: Population based cohort including 61 378 people with OCD and 613 780 unaffected people matched (1:10) on sex, birth year, and county of residence; sibling cohort consisting of 34 085 people with OCD and 47 874 unaffected full siblings. Cohorts were followed up for a median time of 8.1 years during the period from 1 January 1973 to 31 December 2020. MAIN OUTCOME MEASURES: All cause and cause specific mortality.RESULTS: 4787 people with OCD and 30 619 unaffected people died during the study period (crude mortality rate 8.1 and 5.1 per 1000 person years, respectively). In stratified Cox proportional hazards models adjusted for birth year, sex, county, migrant status (born in Sweden versus abroad), and sociodemographic variables (latest recorded education, civil status, and family income), people with OCD had an increased risk of all cause mortality (hazard ratio 1.82, 95% confidence interval 1.76 to 1.89) and mortality due to natural causes (1.31, 1.27 to 1.37) and unnatural causes (3.30, 3.05 to 3.57). Among the natural causes of death, those due to endocrine, nutritional, and metabolic diseases, mental and behavioural disorders, and diseases of the nervous, circulatory, respiratory, digestive, and genitourinary systems were higher in the OCD cohort. Conversely, the risk of death due to neoplasms was lower in the OCD cohort compared with the unaffected cohort. Among the unnatural causes, suicide showed the highest hazard ratio, followed by accidents. The results were robust to adjustment for psychiatric comorbidities and familial confounding.CONCLUSIONS: Non-communicable diseases and external causes of death, including suicides and accidents, were major contributors to the risk of mortality in people with OCD. Better surveillance, prevention, and early intervention strategies should be implemented to reduce the risk of fatal outcomes in people with OCD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
700 | 1 | a Isomura, Kayokou Karolinska Institute,Karolinska Institutet4 aut |
700 | 1 | a Lichtenstein, Paulu Karolinska Institute,Karolinska Institutet4 aut |
700 | 1 | a Larsson, Henrik,d 1975-u Örebro University,Karolinska Institute,Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)hiln |
700 | 1 | a Kuja-Halkola, Ralfu Karolinska Institute,Karolinska Institutet4 aut |
700 | 1 | a Chang, Zhengu Karolinska Institute,Karolinska Institutet4 aut |
700 | 1 | a D'Onofrio, Brian M.u Karolinska Institute,Karolinska Institutet,Indiana University4 aut |
700 | 1 | a Brikell, Isabellu Karolinska Institute,Karolinska Institutet,Aarhus University,University of Bergen4 aut |
700 | 1 | a Rück, Christianu Karolinska Institute,Karolinska Institutet4 aut |
700 | 1 | a Sidorchuk, Annau Karolinska Institute,Karolinska Institutet4 aut |
700 | 1 | a Mataix-Cols, Davidu Karolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Innovations in pediatric mental health,Forskargrupper vid Lunds universitet,Lund University Research Groups,Stockholm Regional Council4 aut0 (Swepub:lu)da5182ma |
710 | 2 | a Karolinska Instituteb Karolinska Institutet4 org |
773 | 0 | t BMJ (Clinical Research Edition)d : BMJ Publishing Group Ltdg 384q 384x 0959-8138x 1756-1833 |
773 | 0 | t BMJd : BMJ Publishing Group Ltdg 384q 384x 0959-8146 |
856 | 4 | u https://doi.org/10.1136/bmj-2023-077564y Fulltext |
856 | 4 | u http://dx.doi.org/10.1136/bmj-2023-077564x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-111022 |
856 | 4 8 | u https://doi.org/10.1136/bmj-2023-077564 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:238233033 |
856 | 4 8 | u https://lup.lub.lu.se/record/5bedb531-2142-4f7f-9957-9b6d8d35bf3d |
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