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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03729naa a2200421 4500 | |
| 001 | oai:DiVA.org:oru-24221 | |
| 003 | SwePub | |
| 008 | 120803s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-242212 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1600-0463.2012.02884.x2 DOI |
| 040 | a (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Rathsman, Sandrau Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden4 aut |
| 245 | 1 0 | a Elution of antitransglutaminase antibodies from duodenal biopsies :b a novel approach in the diagnosis of celiac disease |
| 264 | c 2012-03-24 | |
| 264 | 1 | a Hoboken, USA :b Wiley-Blackwell,c 2012 |
| 338 | a print2 rdacarrier | |
| 520 | a Celiac disease (CeD) is a disease more prevalent and multisymptomatic than was earlier recognized. Whereas prompt initiation of gluten-free diet (GFD) is beneficial in relieving the symptoms, an accurate CeD diagnosis is necessary also to avoid years of restricted diet on uncertain grounds. We propose a new diagnostic method, based on elution of deposited antibodies against transglutaminase (anti-tTG) from duodenal biopsies in patients with symptoms and screening serology analyses suggestive of CeD. The eluates were analyzed in a Phadia 250 fluoroimmunoassay, demonstrating elevated concentrations of anti-tTG in CeD patients, corresponding to serology and histopathology findings. In one case histology was inconclusive, displaying only unspecific inflammation, but eluted anti-tTG was positive. This patient has clinically improved following GFD. We conclude that our novel method represents a new tool in the diagnostic work up in CeD. The detection of deposited anti-tTG at the site of inflammation appears to provide a high sensitivity and specificity using a technique that is quick, simple and reliable. Further studies are needed for optimization and elucidation of suitable applications for this elution method. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng |
| 653 | a Celiac disease | |
| 653 | a antitransglutaminase antibodies | |
| 653 | a elution | |
| 653 | a borderline cases | |
| 653 | a Medicin | |
| 653 | a Medicine | |
| 700 | 1 | a Tysk, Curt,d 1949-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)ctk |
| 700 | 1 | a Eriksson, Suneu Department of Laboratory Medicine/Pathology, Örebro University Hospital, Örebro, Sweden4 aut |
| 700 | 1 | a Hultgren, Olof,d 1970-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)ovhn |
| 700 | 1 | a Åberg, Anna-Karinu Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden4 aut |
| 700 | 1 | a Olcén, Peru Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden4 aut |
| 710 | 2 | a Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Swedenb Institutionen för hälsovetenskap och medicin4 org |
| 773 | 0 | t Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)d Hoboken, USA : Wiley-Blackwellg 120:8, s. 666-674q 120:8<666-674x 0903-4641x 1600-0463 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-24221 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1600-0463.2012.02884.x |
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