Infection induced chronic inflammation and it's association with prostate cancer initiation and progression

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Fältnamn	Indikatorer	Metadata
000		03879nam a2200469 4500
001		oai:DiVA.org:oru-28466
003		SwePub
008		130325s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
020		a 9789176689202q print
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-284662 URI
040		a (SwePub)oru
041		a engb eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a dok2 swepub-publicationtype
100	1	a Davidsson, Sabina,d 1972-u Örebro universitet,Institutionen för hälsovetenskap och medicin4 aut0 (Swepub:oru)sdn
245	1 0	a Infection induced chronic inflammation and it's association with prostate cancer initiation and progression
264	1	a Örebro :b Örebro universitet,c 2013
300		a 65 s.
338		a print2 rdacarrier
490	0	a Örebro Studies in Medicine,x 1652-4063 ;v 86
520		a An association between cancer development and inflammation has long been suggested. Approximately 20% of all human cancers in adults are assumed to result from chronic inflammation. The aim of this thesis was to investigate if infection-induced chronic inflammation plays a role in prostate carcinogenesis.Our results revealed a greater infiltration of the bacterium Propionibacterium acnes in the prostate tissue obtained from men with prostate cancer compared to men without any histological evidence of the disease. These findings indicate that prostate cancer could potentially be included in the list of cancers with an infectious etiology.Further, we investigated whether chronic inflammation has a role in disease progression. Our results demonstrated that men with lethal prostate cancer had pronounced infiltration of immune cells with suppressive function of the anti-tumor immune response compared to men with a more indolent prostate cancer.Confirmation of our results may open up avenues for targeted prostate cancer treatment by offering men with chronic inflammation alternative therapies such as anti-inflammatory drugs. If the involvement of P. acnes in prostate cancer development is replicated in other studies, vaccination therapies may be feasible. To further individualize prostate cancer therapy, bolstering the anti-tumor immune response in order to reduce tumor progression may be determined to be advantageous for some patients.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a Prostate cancer
653		a chronic inflammation
653		a CD4 helper T cells
653		a CD8 cytotoxic T cells
653		a regulatory T cells
653		a Propionibacterium acnes
653		a Medicine
653		a Medicin
700	1	a Andrén, Ove,c Professoru Örebro universitet,Institutionen för hälsovetenskap och medicin4 ths0 (Swepub:oru)oan
700	1	a Söderquist, Bo,c Professoru Örebro universitet,Institutionen för läkarutbildning4 ths0 (Swepub:oru)bost
700	1	a Rider, Jennifer,c ScDu Örebro University Hospital, Sweden Department of Epidemiology, Harvard School Of Public Health; Department of Medicine, Harvard Medical School4 ths
700	1	a Helenius, Gisela,c Associate Professoru Örebro universitet,Institutionen för hälsovetenskap och medicin4 ths0 (Swepub:oru)ghs
700	1	a Damber, Jan-Erik,c Professoru Göteborgs universitet4 opn
710	2	a Örebro universitetb Institutionen för hälsovetenskap och medicin4 org
856	4	u https://oru.diva-portal.org/smash/get/diva2:612760/SUMMARY01.pdfy summary
856	4	u https://oru.diva-portal.org/smash/get/diva2:612760/COVER01.pdfy cover
856	4	u https://oru.diva-portal.org/smash/get/diva2:612760/SPIKBLAD01.pdfy spikblad
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-28466

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Av författaren/redakt...: Davidsson, Sabin ...; Andrén, Ove, Pro ...; Söderquist, Bo, ...; Rider, Jennifer, ...; Helenius, Gisela ...; Damber, Jan-Erik ...

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