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Anti-transglutamina...
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Stenberg, Reidun,1954-Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Centre for Rehabilitation Research, Region Örebro County, Örebro, Sweden
(författare)
Anti-transglutaminase 6 antibodies in children and young adults with cerebral palsy
- Artikel/kapitelEngelska2014
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Hindawi Publishing Corporation,2014
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LIBRIS-ID:oai:DiVA.org:oru-42602
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-42602URI
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https://doi.org/10.1155/2014/237107DOI
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Språk:engelska
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Sammanfattning på:engelska
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Objectives: We have previously reported a high prevalence of gluten-related serological markers (GRSM) in children and young adults with cerebral palsy (CP). The majority had no enteropathy to suggest coeliac disease (CD). Antibodies against transglutaminase 6 (anti-TG6) represent a new marker associated with gluten-related neurological dysfunction. The aim of this study was to investigate the prevalence of anti-TG6 antibodies in this group of individuals with an early neurological injury resulting in CP.Materials and Methods: Sera from 96 patients with CP and 36 controls were analysed for IgA/IgG class anti-TG6 by ELISA.Results: Anti-TG6 antibodies were found in 12/96 (13%) of patients with CP compared to 2/36 (6%) in controls. The tetraplegic subgroup of CP had a significantly higher prevalence of anti-TG6 antibodies 6/17 (35%) compared to the other subgroups and controls. There was no correlation of anti-TG6 autoantibodies with seropositivity to food proteins including gliadin.Conclusions: An early brain insult and associated inflammation may predispose to future development of TG6 autoimmunity.
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Hadjivassiliou, MariosDepartment of Neurology and Department of Neuroradiology,The Royal Hallamshire Hospital, Sheffield, UK
(författare)
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Aeschlimann, PascaleMatrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK
(författare)
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Hoggard, NigelDepartment of Neurology and Department of Neuroradiology,The Royal Hallamshire Hospital, Sheffield, UK
(författare)
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Aeschlimann, DanielMatrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK
(författare)
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Örebro universitetInstitutionen för hälsovetenskap och medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Autoimmune Diseases: Hindawi Publishing Corporation2090-04222090-0430
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