Long-term follow-up in patients treated with curative electrochemotherapy for cancer in the oral cavity and oropharynx

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Long-term follow-up in patients treated with curative electrochemotherapy for cancer in the oral cavity and oropharynx

Landström, Fredrik, 1966- (author): Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden

Reizenstein, Johan (author): Department of Oncology, Örebro University Hospital, Örebro, Sweden

Adamsson, Gun-Britt (author): Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden

von Beckerath, Mathias, 1966- (author): Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden

Möller, Claes, 1950- (author): Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Audiology, Örebro University Hospital, Örebro, Sweden

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2015-06-10
2015
English.
In: Acta Oto-Laryngologica. - : Informa UK Limited. - 0001-6489 .- 1651-2251. ; 135:10, s. 1070-1078

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Conclusion: ECT can be a safe curative mono modality treatment, especially in tongue cancer. The future role for ECT in head and neck cancer needs to be further investigated.Introduction: Electrochemotherapy (ECT) is a cancer treatment modality that uses electroporation to increase the intracellular accumulation of hydrophilic chemotherapeutic drugs, especially bleomycin.Objectives: To report the 5-year local tumor control, safety of treatment and survival after ECT, and the 1-year quality-of-life (QoL) data.Materials and methods: Nineteen patients with primary head and neck cancer were included and treated with ECT with curative intent. All except one patient had squamous cell carcinoma (SCC). Radiotherapy (RT) was performed in all patients with SCC and tumor infiltration ‡5 mm. The EORTC H&N 35 questionnaire was used at baseline and 12 months after treatment. The Wilcoxon signed rank test and McNemar’s test were used for paired data and Mann Whitney U-test and Fishers exact test were used for independent data (sub-group comparison).Results: There were no local recurrences in the follow-up period. Thirteen patients were treated with adjuvant RT. The six patients that were treated with ECT alone were tumor-free and alive 5 years after treatment. There was one serious adverse event reported; aspiration after treatment of a tongue base tumor. The tumor-specific 5-year survival was 75%. The QoL outcome 1 year after ECT showed a significant increase in problems with senses (taste, smell), speech, mouth opening and xerostomia. The QoL outcome also showed worse outcome in the smoking patients regarding speech, in the patients receiving adjuvant RT regarding mouth dryness and swallowing and in the patients with non-tongue oral cavity cancer regarding need for painkillers.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)

Keyword

Electrochemotherapy
bleomycin
head and neck cancer
squamous cell carcinoma
quality-of-life
local control
survival
Onkologi
Oncology
Oto-rhino-laryngologi
Oto-Rhino-Laryngology

Publication and Content Type

ref (subject category)
art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Otorhinolaryngol ...

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By the university: Örebro University

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