SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:oru-46583"
 

Sökning: onr:"swepub:oai:DiVA.org:oru-46583" > Maternal vaccinatio...

  • Ludvigsson, Jonas F.,1969-Karolinska Institutet,Region Örebro län,Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden (författare)

Maternal vaccination against H1N1 influenza and offspring mortality : population based cohort study and sibling design

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • 2015-11-16
  • London, United Kingdom :BMJ Publishing Group Ltd,2015
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-46583
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-46583URI
  • https://doi.org/10.1136/bmj.h5585DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132456307URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Study question: What is the mortality in offspring of mothers who hadinfluenza A(H1N1)pdm09 vaccination during pregnancy?Methods: This was a prospective population based cohort study in seven healthcare regions in Sweden based on vaccinations taking place between 2 October 2009 and 26 November 2010. H1N1 vaccination data were linked with pregnancy and birth characteristics and offspring mortality data in 275 500 births (of which 1203 were stillbirths) from 137 886 mothers. Of these offspring, 41 183 had been exposed to vaccination with Pandemrix, a monovalent AS03 adjuvanted H1N1 influenza vaccine, during fetal life. A primary comparison group consisted of pregnancies of women who were not vaccinated during the same calendar period. In a second comparison, non-exposed siblings of infants prenatally exposed to vaccination were used as controls. Cox regression was used to estimate hazard ratios for stillbirth, early neonatal mortality (days 0-6 after birth), and subsequent mortality (beginning on day 7) in vaccinated versus nonvaccinated women, adjusting for mother’s age at delivery, body mass index, parity, smoking, country of birth, and disposable income and for sex of offspring.Study answer and limitations: The results of this study suggest that AS03 adjuvanted H1N1 vaccination during pregnancy does not affect the risk of stillbirth, early neonatal death, or later mortality in the offspring. During follow-up, 1172 stillbirths, 380 early neonatal deaths, and 706 deaths thereafter occurred. Compared with general population controls, this corresponded to adjusted hazard ratios of 0.83 (95% confidence interval 0.65 to 1.04) for stillbirth, 0.71 (0.44 to 1.14) for early neonatal death, and 0.97 (0.69 to 1.36) for later death. When siblings were used as controls, adjusted hazard ratios were 0.88 (0.59 to 1.30) for stillbirth, 0.82 (0.46 to 1.49) for early neonatal death, and 0.78 (0.52 to 1.19) for later death. Limitations of the study include lack of data on miscarriage before gestational week 22, inability to ascertain which mothers had pandemic flu during pregnancy, and lack of data on factors influencing the decision to vaccinate during pregnancy.What this study adds: H1N1 vaccination during pregnancy is not associated with adverse fetal outcome or offspring mortality, including when familial factors are taken into account.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ström, PeterKarolinska Institutet (författare)
  • Lundholm, CeciliaKarolinska Institutet (författare)
  • Cnattingius, SvenKarolinska Institutet (författare)
  • Ekbom, AndersKarolinska Institutet (författare)
  • Örtqvist, ÅkeKarolinska Institutet (författare)
  • Feltelius, NilsMedical Product Agency, Uppsala, Sweden (författare)
  • Granath, FredrikKarolinska Institutet (författare)
  • Stephansson, OlofKarolinska Institutet (författare)
  • Region Örebro länDepartment of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMJ. British Medical JournalLondon, United Kingdom : BMJ Publishing Group Ltd3510959-81460959-535X
  • Ingår i:BMJLondon, United Kingdom : BMJ Publishing Group Ltd3511756-1833

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy