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Sökning: onr:"swepub:oai:DiVA.org:oru-46583" > Maternal vaccinatio...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005035naa a2200457 4500
001oai:DiVA.org:oru-46583
003SwePub
008151118s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:132456307
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-465832 URI
0247 a https://doi.org/10.1136/bmj.h55852 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1324563072 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ludvigsson, Jonas F.,d 1969-u Karolinska Institutet,Region Örebro län,Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)jsln
2451 0a Maternal vaccination against H1N1 influenza and offspring mortality :b population based cohort study and sibling design
264 c 2015-11-16
264 1a London, United Kingdom :b BMJ Publishing Group Ltd,c 2015
338 a print2 rdacarrier
520 a Study question: What is the mortality in offspring of mothers who hadinfluenza A(H1N1)pdm09 vaccination during pregnancy?Methods: This was a prospective population based cohort study in seven healthcare regions in Sweden based on vaccinations taking place between 2 October 2009 and 26 November 2010. H1N1 vaccination data were linked with pregnancy and birth characteristics and offspring mortality data in 275 500 births (of which 1203 were stillbirths) from 137 886 mothers. Of these offspring, 41 183 had been exposed to vaccination with Pandemrix, a monovalent AS03 adjuvanted H1N1 influenza vaccine, during fetal life. A primary comparison group consisted of pregnancies of women who were not vaccinated during the same calendar period. In a second comparison, non-exposed siblings of infants prenatally exposed to vaccination were used as controls. Cox regression was used to estimate hazard ratios for stillbirth, early neonatal mortality (days 0-6 after birth), and subsequent mortality (beginning on day 7) in vaccinated versus nonvaccinated women, adjusting for mother’s age at delivery, body mass index, parity, smoking, country of birth, and disposable income and for sex of offspring.Study answer and limitations: The results of this study suggest that AS03 adjuvanted H1N1 vaccination during pregnancy does not affect the risk of stillbirth, early neonatal death, or later mortality in the offspring. During follow-up, 1172 stillbirths, 380 early neonatal deaths, and 706 deaths thereafter occurred. Compared with general population controls, this corresponded to adjusted hazard ratios of 0.83 (95% confidence interval 0.65 to 1.04) for stillbirth, 0.71 (0.44 to 1.14) for early neonatal death, and 0.97 (0.69 to 1.36) for later death. When siblings were used as controls, adjusted hazard ratios were 0.88 (0.59 to 1.30) for stillbirth, 0.82 (0.46 to 1.49) for early neonatal death, and 0.78 (0.52 to 1.19) for later death. Limitations of the study include lack of data on miscarriage before gestational week 22, inability to ascertain which mothers had pandemic flu during pregnancy, and lack of data on factors influencing the decision to vaccinate during pregnancy.What this study adds: H1N1 vaccination during pregnancy is not associated with adverse fetal outcome or offspring mortality, including when familial factors are taken into account.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Ström, Peteru Karolinska Institutet4 aut
7001 a Lundholm, Ceciliau Karolinska Institutet4 aut
7001 a Cnattingius, Svenu Karolinska Institutet4 aut
7001 a Ekbom, Andersu Karolinska Institutet4 aut
7001 a Örtqvist, Åkeu Karolinska Institutet4 aut
7001 a Feltelius, Nilsu Medical Product Agency, Uppsala, Sweden4 aut
7001 a Granath, Fredriku Karolinska Institutet4 aut
7001 a Stephansson, Olofu Karolinska Institutet4 aut
7102 a Region Örebro länb Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden4 org
7730 t BMJ. British Medical Journald London, United Kingdom : BMJ Publishing Group Ltdg 351q 351x 0959-8146x 0959-535X
7730 t BMJd London, United Kingdom : BMJ Publishing Group Ltdg 351q 351x 1756-1833
8564 u https://doi.org/10.1136/bmj.h5585y Fulltext
8564 u https://www.bmj.com/content/351/bmj.h5585.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-46583
8564 8u https://doi.org/10.1136/bmj.h5585
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132456307

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