Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014

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Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014

Demczuk, Walter (author): Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

Martin, Irene (author): Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

Peterson, Shelley (author): Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

Bharat, Amrita (author): Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

Van Domselaar, Gary (author): Science Technology Cores and Services Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada

Graham, Morag (author): Science Technology Cores and Services Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada

Lefebvre, Brigitte (author): Laboratoire de Santé Publique du Québec, Ste-Anne-de-Bellevue QC, Canada

Allen, Vanessa (author): Public Health Ontario Laboratories, Toronto ON, Canada

Hoang, Linda (author): British Columbia Centres for Disease Control Public Health Microbiology & Reference Laboratory, Vancouver BC, Canada

Tyrrell, Greg (author): Provincial Laboratory for Public Health, Edmonton, Canada

Horsman, Greg (author): Saskatchewan Disease Control Laboratory, Regina, Canada

Wylie, John (author): Cadham Provincial Laboratory, Winnipeg, Canada

Haldane, David (author): Queen Elizabeth II Health Sciences Centre, Halifax, Canada

Archibald, Chris (author): Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Canada

Wong, Tom (author): First Nations and Inuit Health Branch, Health Canada, Ottawa, Canada

Unemo, Magnus, 1970- (author): Örebro universitet,Institutionen för hälsovetenskaper,Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

Mulvey, Michael R (author): Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

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Washington, USA : American Society for Microbiology, 2016
2016
English.
In: Journal of Clinical Microbiology. - Washington, USA : American Society for Microbiology. - 0095-1137 .- 1098-660X. ; 54:5, s. 1304-1313

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

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Abstract Subject headings

The emergence of Neisseria gonorrhoeae with decreased susceptibility to cephalosporins and azithromycin resistance (AZM-R) represent a public health threat of untreatable gonorrhoea infections. Genomic epidemiology through whole genome sequencing was used to describe the emergence, dissemination, and spread of AZM-R strains. The genomes of 213 AZM-R and 23 AZM-susceptible N. gonorrhoeae isolates collected in Canada from 1989 to 2014 were sequenced. Core single nucleotide polymorphism (SNP) phylogenomic analysis resolved 246 isolates into 13 lineages. High-level AZM-R (minimum inhibitory concentration ≥256 μg/ml) was found in 5 phylogenetically diverse isolates, all of which possessed the A2059G mutation (Escherichia coli numbering) in all four 23S rRNA alleles. One high-level AZM-R isolate collected in 2009 concurrently had decreased susceptibility to ceftriaxone (MIC=0.125 μg/ml). An increase in the number of 23S rRNA alleles with the C2611T mutations (E. coli numbering) conferred low to moderate AZM-R (2 to 4 and 8 to 32 μg/mL, respectively). Low level AZM-R was also associated with mtrR promoter mutations including -35A deletion and the presence of N. meningitidis-like sequences. Geographic and temporal phylogenetic clustering indicate emergent AZM-R strains arise independently and can then rapidly expand clonally in a region through local sexual networks.

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By the author/editor: Demczuk, Walter; Martin, Irene; Peterson, Shelle ...; Bharat, Amrita; Van Domselaar, G ...; Graham, Morag; show more...; Lefebvre, Brigit ...; Allen, Vanessa; Hoang, Linda; Tyrrell, Greg; Horsman, Greg; Wylie, John; Haldane, David; Archibald, Chris; Wong, Tom; Unemo, Magnus, 1 ...; Mulvey, Michael ...; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Microbiology

Articles in the publication: Journal of Clini ...

By the university: Örebro University

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Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014

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