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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04578naa a2200457 4500 | |
| 001 | oai:DiVA.org:oru-51070 | |
| 003 | SwePub | |
| 008 | 160628s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-510702 URI |
| 024 | 7 | a https://doi.org/10.1016/j.envint.2016.06.0202 DOI |
| 040 | a (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Pan, Yitaou Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China4 aut |
| 245 | 1 0 | a Associations of urinary 5-methyl-2'-deoxycytidine and 5-hydroxymethyl-2'-deoxycytidine with phthalate exposure and semen quality in 562 Chinese adult men |
| 264 | 1 | a Oxford, United Kingdom :b Elsevier,c 2016 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agencies:National Basic Research Program of China (973) 2013CB945204Chinese Academy Of Sciences XDB14040202National Natural Science Foundation of China 21477127 | |
| 520 | a 5-methyl-2'-deoxycytidine (5mdC) and 5-hydroxymethyl-2'-deoxycytidine (5hmdC), products of DNA methylation and hydroxymethylation processes, have been detected previously in human urine, but their associations with environmental chemicals or healthy outcomes are unclear. The present investigation explored the associations between urinary 5mdC and 5hmdC with phthalate exposure and semen quality. We assessed semen parameters including sperm concentration, motility, and morphology, before measuring urinary 5mdC, 5hmdC and 13 phthalate metabolites among 562 subfertile men from Nanjing, China. Urinary 5mdC and 5hmdC were positively associated with the levels of low molecular weight phthalate metabolites (Low-MWP), high molecular weight phthalate metabolites (High-MWP), and the sum of all phthalate metabolites (ΣPAEs), respectively. Urinary 5mdC was associated with below-reference sperm concentration (odds ratios for increasing quartiles=1.0, 2.2, 3.0, 2.0; p for trend =0.02), sperm motility (1.0, 1.1, 1.9, 1.3; p for trend =0.05), and sperm morphology (1.0, 1.4, 2.3, 1.5; p for trend =0.05). Sperm concentration was associated with the highest quartile of urinary 5hmdC [odds ratio=1.9 (95% CI: 1.1, 3.6)]. Our findings showed significant associations between urinary 5mdC and 5hmdC with phthalate metabolites and semen parameters, which suggested urinary 5mdC and 5hmdC may be promising biomarkers in future epidemiological studies. | |
| 650 | 7 | a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Geovetenskap och miljövetenskapx Miljövetenskap0 (SwePub)105022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Earth and Related Environmental Sciencesx Environmental Sciences0 (SwePub)105022 hsv//eng |
| 653 | a DNA methylation | |
| 653 | a hydroxymethylation | |
| 653 | a 5mdC | |
| 653 | a 5hmdC | |
| 653 | a phthalate metabolites | |
| 653 | a semen quality | |
| 700 | 1 | a Jing, Junu Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China4 aut |
| 700 | 1 | a Yeung, Leo W. Y.,d 1981-u Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Centre (MTM)4 aut0 (Swepub:oru)lyg |
| 700 | 1 | a Sheng, Nanu Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China4 aut |
| 700 | 1 | a Zhang, Hongxiau Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China4 aut |
| 700 | 1 | a Yao, Bingu Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, PR China4 aut |
| 700 | 1 | a Dai, Jiayinu Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China4 aut |
| 710 | 2 | a Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR Chinab Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China4 org |
| 773 | 0 | t Environment Internationald Oxford, United Kingdom : Elsevierg 94, s. 583-590q 94<583-590x 0160-4120x 1873-6750 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51070 |
| 856 | 4 8 | u https://doi.org/10.1016/j.envint.2016.06.020 |
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