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Homeostasis of the ...
Homeostasis of the Gut Barrier and Potential Biomarkers
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- Wells, Jerry M. (författare)
- Host-Microbe Interactomics, Animal Sciences, Wageningen University, Wageningen, The Netherlands
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- Brummer, Robert J., 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Nutrition-Gut-Brain Interactions Research Centre
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- Derrien, Muriel (författare)
- Centre Daniel Carasso, Danone Research B. V., Palaiseau, France
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- MacDonald, Thomas T. (författare)
- Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
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- Troost, Freddy (författare)
- Division of Gastroenterology-Hepatology, Department of Internal Medicine, University Hospital Maastricht, Maastricht University Medical Centre+ (Maastricht UMC+), Maastricht, The Netherlands
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- Cani, Patrice D. (författare)
- Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO ), Metabolism and Nutrition Research Group, Université Catholique de Louvain, Brussels, Belgium
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- Theodorou, Vassilia (författare)
- Neuro-Gastroenterology and Nutrition Group, Institut National de la Recherche Agronomique, Toulouse, France
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- Dekker, Jan (författare)
- Host-Microbe Interactomics, Animal Sciences, Wageningen University, Wageningen, The Netherlands
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- Méheust, Agnes (författare)
- The International Life Sciences Institute European Branch, Brussels, Belgium
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- de Vos, Willem M. (författare)
- Laboratory of Microbiology, Wageningen Uiversity and Research (WUR), Wageningen, The Netherlands
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- Mercenier, Annick (författare)
- Nutrition & Health Research, Nestlé Research Center, Lausanne, Switzerland
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- Nauta, Arjen (författare)
- FrieslandCampina, Amersfoort, The Netherlands
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- Garcia-Rodenas, Clara L (författare)
- Nutrition & Health Research, Nestlé Research Center, Lausanne, Switzerland
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(creator_code:org_t)
- Bethesda, USA : American Physiological Society, 2017
- 2017
- Engelska.
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Ingår i: American Journal of Physiology - Gastrointestinal and Liver Physiology. - Bethesda, USA : American Physiological Society. - 0193-1857 .- 1522-1547. ; 312:3, s. G171-G193
- Relaterad länk:
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https://www.physiolo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the production of sIgA and antimicrobial peptides and proteins. With exception of sIgA the expression of these protective barrier factors is largely controlled by innate immune recognition of microbial molecular ligands. Several specialized adaptations and checkpoints are operating in the mucosa to scale the immune response according to the threat and prevent overreaction to the trillions of symbionts inhabiting the human intestine. A healthy microbiota plays a key role influencing epithelial barrier functions. However, perturbation of gut barrier homeostasis can lead to increased inflammatory signaling, increased epithelial permeability and dysbiosis of the microbiota, which are recognized to play a role in the pathophysiology of gastrointestinal disorders. Additionally, the gut-brain signaling may be affected by prolonged mucosal immune activation, leading to increased afferent sensory signaling and abdominal symptoms. In turn, neuronal mechanisms can affect the intestinal barrier partly by activation of the HPA-axis and both mast cell-dependent as well as mast cell- independent mechanisms. Several biomarkers have been used to measure gut permeability and loss of barrier integrity in patients but there remains a need to explore their use in assessing impact of nutritional factors on gut barrier function. Future studies should aim to establish normal ranges of the available biomarkers and their predictive value for gut health in human cohorts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Gut barrier
- antimicrobial peptides
- microbiota
- epithelial permeability
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- Av författaren/redakt...
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Wells, Jerry M.
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Brummer, Robert ...
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Derrien, Muriel
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MacDonald, Thoma ...
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Troost, Freddy
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Cani, Patrice D.
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Theodorou, Vassi ...
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Dekker, Jan
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Méheust, Agnes
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de Vos, Willem M ...
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Mercenier, Annic ...
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Nauta, Arjen
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Garcia-Rodenas, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Fysiologi
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American Journal ...
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Örebro universitet