SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:oru-58676"
 

Sökning: onr:"swepub:oai:DiVA.org:oru-58676" > Whole-genome analys...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008888naa a2200697 4500
001oai:DiVA.org:oru-58676
003SwePub
008170712s2012 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:500fcc30-505e-4e13-a848-5a7f23f93634
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-586762 URI
0247 a https://doi.org/10.1038/ng.22142 DOI
0247 a https://lup.lub.lu.se/record/24945422 URI
040 a (SwePub)orud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Harris, Simon R.u Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom4 aut
2451 0a Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing
264 c 2012-03-11
264 1b Nature Publishing Group,c 2012
338 a print2 rdacarrier
520 a Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV) biovars from temporally and geographically diverse sources. Our analysis shows that predicting phylogenetic structure using ompA, which is traditionally used to classify Chlamydia, is misleading because extensive recombination in this region masks any true relationships present. We show that in many instances, ompA is a chimera that can be exchanged in part or as a whole both within and between biovars. We also provide evidence for exchange of, and recombination within, the cryptic plasmid, which is another key diagnostic target. We used our phylogenetic framework to show how genetic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the epidemic LGV serotype L2b.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
7001 a Clarke, Ian N.u Molecular Microbiology Group, Southampton General Hospital, University Medical School, Southampton, United Kingdom4 aut
7001 a Seth-Smith, Helena M. B.u Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom4 aut
7001 a Solomon, Anthony W.u Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom4 aut
7001 a Cutcliffe, Lesley T.u Molecular Microbiology Group, Southampton General Hospital, University Medical School, Southampton, United Kingdom4 aut
7001 a Marsh, Peteru Health Protection Agency, Public Health Laboratory Southampton, Southampton General Hospital, Southampton, United Kingdom4 aut
7001 a Skilton, Rachel J.u Molecular Microbiology Group, Southampton General Hospital, University Medical School, Southampton, United Kingdom4 aut
7001 a Holland, Martin J.u Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom4 aut
7001 a Mabey, Davidu Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom4 aut
7001 a Peeling, Rosanna W.u Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom4 aut
7001 a Lewis, David A.u Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Sexually Transmitted Infections Reference Centre, National Health Laboratory Service, National Institute for Communicable Diseases, Johannesburg, South Africa; Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa4 aut
7001 a Spratt, Brian G.u Department of Infectious Disease Epidemiology, St. Mary's Hospital Campus, Imperial College, London, United Kingdom4 aut
7001 a Unemo, Magnus,d 1970-u Region Örebro län,Department of Laboratory Medicine and Clinical Microbiology, National Reference Laboratory for Pathogenic Neisseria, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)muo
7001 a Persson, Kennethu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-kpe
7001 a Bjartling, Carinau Lund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups4 aut0 (Swepub:lu)obst-cbj
7001 a Brunham, Robertu British Columbia Centre for Disease Control, Vancouver BC, Canada4 aut
7001 a de Vries, Henry J. C.u Department of Dermatology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Sexually Transmitted Infections Outpatient Clinic, Infectious Diseases Cluster, Public Health Service Amsterdam, Amsterdam, Netherlands; Centre for Infection and Immunity Amsterdam, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands4 aut
7001 a Morré, Servaas A.u Department of Medical Microbiology of Infection Prevention, Laboratory of Immunogenetics, Vrije University Medical Center, Amsterdam, Netherlands; Department of Genetics and Cell Biology, Institute of Public Health Genomics, University of Maastricht, Maastricht, Netherlands4 aut
7001 a Speksnijder, Arjenu Geneeskundige en Gezondheidsdienst (GGD), Amsterdam, The Netherlands4 aut
7001 a Bébéar, Cecile M.u Unité Sous Contrat (USC) Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Université de Bordeaux, Bordeaux, France; USC Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Institut National de la Recherche Agronomique, Bordeaux, France4 aut
7001 a Clerc, Maiteu Unité Sous Contrat (USC) Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Université de Bordeaux, Bordeaux, France; USC Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Institut National de la Recherche Agronomique, Bordeaux, France4 aut
7001 a de Barbeyrac, Bertilleu Unité Sous Contrat (USC) Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Université de Bordeaux, Bordeaux, France; USC Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Institut National de la Recherche Agronomique, Bordeaux, France4 aut
7001 a Parkhill, Julianu Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom4 aut
7001 a Thomson, Nicholas R.u Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom4 aut
7102 a Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton, United Kingdomb Molecular Microbiology Group, Southampton General Hospital, University Medical School, Southampton, United Kingdom4 org
7730 t Nature Geneticsd : Nature Publishing Groupg 44:4, s. 413-419q 44:4<413-419x 1061-4036x 1546-1718
8564 u https://europepmc.org/articles/pmc3378690?pdf=render
8564 u http://dx.doi.org/10.1038/ng.2214y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-58676
8564 8u https://doi.org/10.1038/ng.2214
8564 8u https://lup.lub.lu.se/record/2494542

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy