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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05968naa a2200529 4500 | |
| 001 | oai:DiVA.org:oru-59353 | |
| 003 | SwePub | |
| 008 | 170824s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-593532 URI |
| 024 | 7 | a https://doi.org/10.1158/0008-5472.CAN-10-38942 DOI |
| 040 | a (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hilvo, Mikau Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland4 aut |
| 245 | 1 0 | a Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression |
| 264 | 1 | a Philadelphia, PA, USA :b American Association for Cancer Research,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many cancers. However, the precise molecular composition of lipids in tumors remains generally poorly characterized. The aim of the present study was to analyze the global lipid profiles of breast cancer, integrate the results to protein expression, and validate the findings by functional experiments. Comprehensive lipidomics was conducted in 267 human breast tissues using ultraperformance liquid chromatography/ mass spectrometry. The products of de novo fatty acid synthesis incorporated into membrane phospholipids, such as palmitate-containing phosphatidylcholines, were increased in tumors as compared with normal breast tissues. These lipids were associated with cancer progression and patient survival, as their concentration was highest in estrogen receptor-negative and grade 3 tumors. In silico transcriptomics database was utilized in investigating the expression of lipid metabolism related genes in breast cancer, and on the basis of these results, the expression of specific proteins was studied by immunohistochemistry. Immunohistochemical analyses showed that several genes regulating lipid metabolism were highly expressed in clinical breast cancer samples and supported also the lipidomics results. Gene silencing experiments with seven genes [ACACA (acetyl-CoA carboxylase α), ELOVL1 (elongation of very long chain fatty acid-like 1), FASN (fatty acid synthase), INSIG1 (insulin-induced gene 1), SCAP (sterol regulatory element-binding protein cleavage-activating protein), SCD (stearoyl-CoA desaturase), and THRSP (thyroid hormone-responsive protein)] indicated that silencing of multiple lipid metabolism-regulating genes reduced the lipidomic profiles and viability of the breast cancer cells. Taken together, our results imply that phospholipids may have diagnostic potential as well as that modulation of their metabolism may provide therapeutic opportunities in breast cancer treatment. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Denkert, Carstenu Institute of Pathology, Berlin, Germany4 aut |
| 700 | 1 | a Lehtinen, Laurau Bio and Process Technology, VTT Technical Research Centre of Finland, Turku, Finland4 aut |
| 700 | 1 | a Müller, Beritu Institute of Pathology, Berlin, Germany4 aut |
| 700 | 1 | a Brockmöller, Scarletu Institute of Pathology, Berlin, Germany4 aut |
| 700 | 1 | a Seppänen-Laakso, Tuulikkiu Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland4 aut |
| 700 | 1 | a Budczies, Janu Institute of Pathology, Berlin, Germany4 aut |
| 700 | 1 | a Bucher, Elmaru Bio and Process Technology, VTT Technical Research Centre of Finland, Turku, Finland4 aut |
| 700 | 1 | a Yetukuri, Laxmanu Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland4 aut |
| 700 | 1 | a Castillo, Sandrau Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland4 aut |
| 700 | 1 | a Berg, Emiliau Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland4 aut |
| 700 | 1 | a Nygren, Heliu Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland4 aut |
| 700 | 1 | a Sysi-Aho, Markou Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland4 aut |
| 700 | 1 | a Griffin, Julian L.u Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Fiehn, Oliveru Genome Center, University of California, Davis CA, United States4 aut |
| 700 | 1 | a Loibl, Sibylleu German Breast Group, GBG-Forschungs GmbH, Neu-Isenburg, Germany4 aut |
| 700 | 1 | a Richter-Ehrenstein, Christianeu cBreast Cancer Center, Charité University Hospital, Berlin, Germany4 aut |
| 700 | 1 | a Radke, Corneliau Institute of Pathology, DRK Klinikum Berlin Köpenick, Berlin, Germany4 aut |
| 700 | 1 | a Hyötyläinen, Tuulia,d 1971-u Örebro universitet,Institutionen för naturvetenskap och teknik,Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland4 aut0 (Swepub:oru)tihn |
| 700 | 1 | a Kallioniemi, Olliu Bio and Process Technology, VTT Technical Research Centre of Finland, Turku, Finland4 aut |
| 700 | 1 | a Iljin, Kristiinau Bio and Process Technology, VTT Technical Research Centre of Finland, Turku, Finland4 aut |
| 700 | 1 | a Oresic, Matej,d 1967-u Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland4 aut0 (Swepub:oru)moc |
| 710 | 2 | a Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finlandb Institute of Pathology, Berlin, Germany4 org |
| 773 | 0 | t Cancer Researchd Philadelphia, PA, USA : American Association for Cancer Researchg 71:9, s. 3236-45q 71:9<3236-45x 0008-5472x 1538-7445 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59353 |
| 856 | 4 8 | u https://doi.org/10.1158/0008-5472.CAN-10-3894 |
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