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Prediction of non-a...
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Orešič, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
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Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
- Article/chapterEnglish2013
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2013-07-04
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Springer,2013
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LIBRIS-ID:oai:DiVA.org:oru-59356
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59356URI
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https://doi.org/10.1007/s00125-013-2981-2DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies:Academy of Finland Sigrid Juselius Foundation Finnish Diabetes Research Foundation Emil Aaltonen Foundation Finnish Medical Foundation Novo Nordisk Foundation Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research - SyMMyS 250114 European Commission LSHM-CT-2005-018734 Innovative Medicines Initiative Joint Undertaking 115372 European Union EFPIA companies
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AIMS/HYPOTHESIS: We examined whether analysis of lipids by ultra-performance liquid chromatography (UPLC) coupled to MS allows the development of a laboratory test for non-alcoholic fatty-liver disease (NAFLD), and how a lipid-profile biomarker compares with the prediction of NAFLD and liver-fat content based on routinely available clinical and laboratory data.METHODS: We analysed the concentrations of molecular lipids by UPLC-MS in blood samples of 679 well-characterised individuals in whom liver-fat content was measured using proton magnetic resonance spectroscopy ((1)H-MRS) or liver biopsy. The participants were divided into biomarker-discovery (n = 287) and validation (n = 392) groups to build and validate the diagnostic models, respectively.RESULTS: Individuals with NAFLD had increased triacylglycerols with low carbon number and double-bond content while lysophosphatidylcholines and ether phospholipids were diminished in those with NAFLD. A serum-lipid signature comprising three molecular lipids ('lipid triplet') was developed to estimate the percentage of liver fat. It had a sensitivity of 69.1% and specificity of 73.8% when applied for diagnosis of NAFLD in the validation series. The usefulness of the lipid triplet was demonstrated in a weight-loss intervention study.CONCLUSIONS/INTERPRETATION: The liver-fat-biomarker signature based on molecular lipids may provide a non-invasive tool to diagnose NAFLD, in addition to highlighting lipid molecular pathways involved in the disease.
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Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)tihn
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Kotronen, AnnaDepartment of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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Gopalacharyulu, PeddintiVTT Technical Research Centre of Finland, Espoo, Finland
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Nygren, HeliVTT Technical Research Centre of Finland, Espoo, Finland
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Arola, JohannaDepartment of Pathology, HUSLAB, University of Helsinki, Helsinki, Finland
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Castillo, SandraVTT Technical Research Centre of Finland, Espoo, Finland
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Mattila, IsmoVTT Technical Research Centre of Finland, Espoo, Finland
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Hakkarainen, AnttiDepartment of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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Borra, Ronald J HTurku PET Centre, University of Turku, Turku, Finland; Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland
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Honka, Miikka-JuhaniTurku PET Centre, University of Turku, Turku, Finland
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Verrijken, AnDepartment of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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Francque, SvenDepartment of Gastroenterology and Hepatology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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Iozzo, PatriciaTurku PET Centre, University of Turku, Turku, Finland; Institute of Clinical Physiology, National Research Council, Pisa, Italy
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Leivonen, MarjaDepartment of Surgery, Helsinki University Central Hospital, Vantaa, Finland
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Jaser, NabilDepartment of Surgery, Helsinki University Central Hospital, Vantaa, Finland
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Juuti, AnneDepartment of Surgery, Helsinki University Central Hospital, Vantaa, Finland
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Sørensen, Thorkild I AInstitute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen, Denmark
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Nuutila, PirjoTurku PET Centre, University of Turku, Turku, Finland
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Van Gaal, LucMedical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland
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Yki-Järvinen, HanneleDepartment of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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Örebro universitetInstitutionen för medicinska vetenskaper
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In:Diabetologia: Springer56:10, s. 2266-22740012-186X1432-0428
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Orešič, Matej, 1 ...
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Hyötyläinen, Tuu ...
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Kotronen, Anna
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Gopalacharyulu, ...
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Nygren, Heli
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Arola, Johanna
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Castillo, Sandra
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Mattila, Ismo
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Verrijken, An
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Francque, Sven
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Iozzo, Patricia
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Leivonen, Marja
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Jaser, Nabil
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Juuti, Anne
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Sørensen, Thorki ...
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Nuutila, Pirjo
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Van Gaal, Luc
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Yki-Järvinen, Ha ...
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Diabetologia
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