Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome

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Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome

Lankinen, Maria A. (författare): VTT Technical Research Centre of Finland, Espoo, Finland; Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland

Schwab, Ursula S. (författare): Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland

Gopalacharyulu, Peddinti (författare): VTT Technical Research Centre of Finland, Espoo, Finland

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Seppänen-Laakso, Tuulikki E. VTT Technical Research Centre of Finland, Espoo, Finland Author ID: 55949278200 Follow this Author (författare): VTT Technical Research Centre of Finland, Espoo, Finland

Yetukuri, L. (författare): VTT Technical Research Centre of Finland, Espoo, Finland

Sysi-Aho, Marko (författare): VTT Technical Research Centre of Finland, Espoo, Finland

Kallio, Petteri (författare): Department of Clinical Nutrition, Food and Health Research Centre, School of Public Health and Clinical Nutrition, , Kuopio, Finland

Suortti, Tapani M. (författare): VTT Technical Research Centre of Finland, Espoo, Finland

Laaksonen, David E. (författare): Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland; Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland

Gylling, Helena K. (författare): Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland

Poutanen, Kaisa S. (författare): VTT Technical Research Centre of Finland, Espoo, Finland; Department of Clinical Nutrition, Food and Health Research Centre, School of Public Health and Clinical Nutrition, , Kuopio, Finland

Kolehmainen, Marjukka (författare): Department of Clinical Nutrition, Food and Health Research Centre, School of Public Health and Clinical Nutrition, , Kuopio, Finland

Oresic, Matej, 1967- (författare): Örebro universitet,Institutionen för medicinska vetenskaper

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Elsevier, 2010
2010
Engelska.
Ingår i: NMCD. Nutrition Metabolism and Cardiovascular Diseases. - : Elsevier. - 0939-4753 .- 1590-3729. ; 20:4, s. 249-57

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

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BACKGROUND AND AIMS: Whole-grain cereals and diets with a low glycemic index may protect against the development of type 2 diabetes and heart disease, but the mechanisms are poorly understood. We studied the effect of carbohydrate modification on serum metabolic profiles, including lipids and branched chain amino acids, and dependencies between these and specific gene expression pathways in adipose tissue.METHODS AND RESULTS: Twenty subjects with metabolic syndrome were selected from the larger FUNGENUT study population, randomized either to a diet high in oat and wheat bread and potato (OWP) or rye bread and pasta (RP). Serum metabolomics analyses were performed using ultra-performance liquid chromatography coupled to electrospray ionization mass spectrometry (UPLC/MS), gas chromatography (GC) and UPLC. In the OWP group multiple proinflammatory lysophosphatidylcholines increased, while in the RP group docosahexaenoic acid (DHA 22:6n-3) increased and isoleucine decreased. mRNA expression of stress reactions- and adipose tissue differentiation-related genes were up-regulated in adipose tissue in the OWP group. In the RP group, however, pathways related to stress reactions and insulin signaling and energy metabolism were down-regulated. The lipid profiles had the strongest association with the changes in the adipose tissue differentiation pathway when using the elastic net regression model of the lipidomic profiles on selected pathways.CONCLUSION: Our results suggest that the dietary carbohydrate modification alters the serum metabolic profile, especially in lysoPC species, and may, thus, contribute to proinflammatory processes which in turn promote adverse changes in insulin and glucose metabolism.

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MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

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NMCD. Nutrition Metabolism and Cardiovascular Diseases (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Lankinen, Maria ...; Schwab, Ursula S ...; Gopalacharyulu, ...; Seppänen-Laakso, ...; Yetukuri, L.; Sysi-Aho, Marko; visa fler...; Kallio, Petteri; Suortti, Tapani ...; Laaksonen, David ...; Gylling, Helena ...; Poutanen, Kaisa ...; Kolehmainen, Mar ...; Oresic, Matej, 1 ...; visa färre...

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