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Sökning: onr:"swepub:oai:DiVA.org:oru-67217" > Antimicrobial resis...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005282naa a2200493 4500
001oai:DiVA.org:oru-67217
003SwePub
008180611s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-672172 URI
0247 a https://doi.org/10.1007/s10096-018-3296-52 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ryan, L.u Department of Clinical Microbiology, St James’s Hospital, Dublin, Ireland4 aut
2451 0a Antimicrobial resistance and molecular epidemiology using whole-genome sequencing of Neisseria gonorrhoeae in Ireland, 2014-2016 :b focus on extended-spectrum cephalosporins and azithromycin
264 c 2018-06-07
264 1b Springer,c 2018
338 a print2 rdacarrier
500 a Funding Agencies:Department of Microbiology. St James's Hospital, Dublin  Irish Research Council fellowship  EPSPD/2015/32 
520 a High-level resistance and treatment failures with ceftriaxone and azithromycin, the first-line agents for gonorrhoea treatment are reported and antimicrobial-resistant Neisseria gonorrhoeae is an urgent public health threat. Our aims were to determine antimicrobial resistance rates, resistance determinants and phylogeny of N. gonorrhoeae in Ireland, 2014-2016. Overall, 609 isolates from four University Hospitals were tested for susceptibility to extended-spectrum cephalosporins (ESCs) and azithromycin by the MIC Test Strips. Forty-three isolates were whole-genome sequenced based on elevated MICs. The resistance rate to ceftriaxone, cefixime, cefotaxime and azithromycin was 0, 1, 2.1 and 19%, respectively. Seven high-level azithromycin-resistant (HLAzi-R) isolates were identified, all susceptible to ceftriaxone. Mosaic penA alleles XXXIV, X and non-mosaic XIII, and G120K plus A121N/D/G (PorB1b), H105Y (MtrR) and A deletion (mtrR promoter) mutations, were associated with elevated ESC MICs. A2059G and C2611T mutations in 23S rRNA were associated with HLAzi-R and azithromycin MICs of 4-32 mg/L, respectively. The 43 whole-genome sequenced isolates belonged to 31 NG-MAST STs. All HLAzi-R isolates belonged to MLST ST1580 and some clonal clustering was observed; however, the isolates differed significantly from the published HLAzi-R isolates from the ongoing UK outbreak. There is good correlation between previously described genetic antimicrobial resistance determinants and phenotypic susceptibility categories for ESCs and azithromycin in N. gonorrhoeae. This work highlights the advantages and potential of whole-genome sequencing to be applied at scale in the surveillance of antibiotic resistant strains of N. gonorrhoeae, both locally and internationally.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653 a High-level azithromycin-resistant Neisseria gonorrhoeae
653 a Ireland
653 a MLST
653 a NG-MAST
653 a Neisseria gonorrhoeae
653 a Resistance determinants
7001 a Golparian, Daniel,d 1984-u Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)degn
7001 a Fennelly, N.u Department of Clinical Microbiology, St James’s Hospital, Dublin, Ireland4 aut
7001 a Rose, L.u Department of Clinical Microbiology, St James’s Hospital, Dublin, Ireland4 aut
7001 a Walsh, P.u Department of Computing, Cork Institute of Technology, Cork, Ireland4 aut
7001 a Lawlor, B.u Department of Computing, Cork Institute of Technology, Cork, Ireland4 aut
7001 a Mac Aogáin, M.u Department of Clinical Microbiology, Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland4 aut
7001 a Unemo, Magnus,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology4 aut0 (Swepub:oru)muo
7001 a Crowley, B.u Department of Clinical Microbiology, St James’s Hospital, Dublin, Ireland; Department of Virology, St James’s Hospital, Dublin, Ireland4 aut
7102 a Department of Clinical Microbiology, St James’s Hospital, Dublin, Irelandb Institutionen för medicinska vetenskaper4 org
7730 t European Journal of Clinical Microbiology and Infectious Diseasesd : Springerg 37:9, s. 1661-1672q 37:9<1661-1672x 0934-9723x 1435-4373
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67217
8564 8u https://doi.org/10.1007/s10096-018-3296-5

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