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Sökning: onr:"swepub:oai:DiVA.org:oru-70944" > The effect of fatty...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005453naa a2200481 4500
001oai:DiVA.org:oru-70944
003SwePub
008190826s2009 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-709442 URI
0247 a https://doi.org/10.1007/s00394-009-0033-y2 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a de Mello, Vanessa D. F.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
2451 0a The effect of fatty or lean fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease
264 c 2009-06-09
264 1b Steinkopff-Verlag,c 2009
338 a print2 rdacarrier
520 a BACKGROUND: Little is known about the effect of fish consumption on gene expression of inflammation-related genes in immune cells in coronary heart disease (CHD).AIM OF THE STUDY: We sought to evaluate the effect of a fatty fish (FF) or a lean fish (LF) diet on the modulation of inflammatory and endothelial function-related genes in peripheral blood mononuclear cells (PBMCs) of subjects with CHD, and its association with serum fatty acid (FA) profile and lipid metabolic compounds.METHODS: Data from 27 patients randomized into an 8-week FF (n = 10; mean +/- SD: 4.3 +/- 0.4 portions of fish per week), LF (n = 11; 4.7 +/- 1.1 portions of fish per week), or control diet (n = 6; 0.6 +/- 0.4 portions of fish per week) were analyzed. The mRNA expression was measured using real-time PCR.RESULTS: The effect of the intervention on the mRNA expression of the genes studied did not differ among groups. In the FF group, however, the decrease in arachidonic acid to eicosapentaenoic acid (AA:EPA) ratio in cholesterol ester and phospholipid fractions strongly correlated with the change in IL1B mRNA levels (r (s) = 0.60, P = 0.06 and r (s) = 0.86, P = 0.002, respectively). In the LF group, the decrease in palmitic acid and total saturated FAs in cholesterol esters correlated with the change in intercellular cell adhesion molecule-1 (ICAM1) expression (r (s) = 0.64, P = 0.04 for both). Circulating levels of soluble ICAM-1 decreased only in the LF group (P < 0.05).CONCLUSIONS: The intake of FF or LF diet did not alter the expression of inflammatory and endothelial function-related genes in PBMCs of patients with CHD. However, the decrease in AA:EPA ratio in serum lipids in the FF group may induce an anti-inflammatory response at mRNA levels in PBMCs. A LF diet might benefit endothelial function, possibly mediated by the changes in serum FA composition.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a Fish Fatty acids
653 a Gene expression
653 a Inflammation
653 a Endothelial function
653 a ICAM
653 a IL-1β
7001 a Erkkilä, Arja T.u Department of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
7001 a Schwab, Ursula S.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland4 aut
7001 a Pulkkinen, Leenau Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
7001 a Kolehmainen, Marjukkau Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
7001 a Atalay, Mustafau Department of Physiology, Institute of Biomedicine, University of Kuopio, Kuopio, Finland4 aut
7001 a Mussalo, Hannau Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland4 aut
7001 a Lankinen, Mariau Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland4 aut
7001 a Oresic, Matej,d 1967-u VTT Technical Research Centre of Finland, Espoo, Finland4 aut0 (Swepub:oru)moc
7001 a Lehto, Seppou Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland4 aut
7001 a Uusitupa, Mattiu Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
7102 a Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finlandb Department of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 org
7730 t European Journal of Nutritiond : Steinkopff-Verlagg 48:8, s. 447-455q 48:8<447-455x 1436-6207x 1436-6215
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70944
8564 8u https://doi.org/10.1007/s00394-009-0033-y

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