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FältnamnIndikatorerMetadata
00012324naa a2201141 4500
001oai:DiVA.org:oru-79153
003SwePub
008200114s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:141071627
009oai:gup.ub.gu.se/280954
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-791532 URI
0247 a https://doi.org/10.1016/j.jalz.2019.03.0042 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1410716272 URI
0247 a https://gup.ub.gu.se/publication/2809542 URI
040 a (SwePub)orud (SwePub)kid (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kim, Minu Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut
2451 0a Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
264 c 2019-05-08
264 1b Elsevier,c 2019
338 a print2 rdacarrier
500 a Funding Agencies:Innovative Medicines Initiative Joint Undertaking under EMIF, Grant number 115372European Union (EU), Appeared in article as European UnionEFPIA companies  European Commission Joint Research Centre, Appeared in article as European Commission, Grant number QLRT-2001-245537670Department of Health of the Basque Government, Grant number  17.0.1.08.12.0000.2.454.01.41142.001.HUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA, Appeared in article as National Institutes of Health, Grant number R15-GM107864
520 a INTRODUCTION: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.METHODS: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.RESULTS: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.DISCUSSION: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Alzheimer's disease
653 a Amyloid
653 a Biomarkers
653 a Brain volume measurements
653 a CSF
653 a Cognitive function measurements
653 a Dementia
653 a EMIF-AD
653 a Metabolomics
653 a Tau
7001 a Snowden, Stuartu Institute of Pharmaceutical Science, King's College London, London, UK; Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK4 aut
7001 a Suvitaival, Tommiu Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut
7001 a Ali, Ashfaqu Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut
7001 a Merkler, David Ju Department of Chemistry, University of South Florida, Tampa, FL, USA4 aut
7001 a Ahmad, Tahminau Institute of Pharmaceutical Science, King's College London, London, UK4 aut
7001 a Westwood, Sarahu Department of Psychiatry, University of Oxford, Oxford, UK4 aut
7001 a Baird, Alisonu Department of Psychiatry, University of Oxford, Oxford, UK4 aut
7001 a Proitsi, Petroulau Karolinska Institutet4 aut
7001 a Nevado-Holgado, Alejou Department of Psychiatry, University of Oxford, Oxford, UK4 aut
7001 a Hye, Abdulu Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut
7001 a Bos, Isabelleu Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands4 aut
7001 a Vos, Stephanieu Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands4 aut
7001 a Vandenberghe, Riku University Hospital Leuven, Leuven, Belgium4 aut
7001 a Teunissen, Charlotteu Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands4 aut
7001 a Ten Kate, Marau Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands4 aut
7001 a Scheltens, Philipu Department of Neurology, Alzheimer Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands4 aut
7001 a Gabel, Silvyu University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium4 aut
7001 a Meersmans, Karenu University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium4 aut
7001 a Blin, Olivieru Service de Pharmacologie Clinique et Pharmacovigilance, Institut de Neurosciences des Systèmes, Aix Marseille University, APHM, INSERM, Marseille, France4 aut
7001 a Richardson, Jillu Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK4 aut
7001 a De Roeck, Ellenu Institute Born-Bunge, University of Antwerp, Antwerp, Belgium4 aut
7001 a Sleegers, Kristelu Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Flanders, Belgium4 aut
7001 a Bordet, Régisu University of Lille, INSERM, CHU, Degenerative and Vascular Cognitive Disorders, Lille, Lille, France4 aut
7001 a Rami, Lorenau Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic-IDIBAPS, Barcelona, Spain4 aut
7001 a Kettunen, Petronellau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xketpe
7001 a Tsolaki, Magdau First Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece4 aut
7001 a Verhey, Fransu Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands4 aut
7001 a Sala, Isabelu Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain4 aut
7001 a Lléo, Albertou Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain4 aut
7001 a Peyratout, Gwendolineu University Hospital of Lausanne, Lausanne, Switzerland4 aut
7001 a Tainta, Mikelu CITA-Alzheimer Foundation, San Sebastian, Spain4 aut
7001 a Johannsen, Peteru Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark4 aut
7001 a Freund-Levi, Yvonne,d 1956-u Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden4 aut0 (Swepub:oru)yfi
7001 a Frölich, Lutzu Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany4 aut
7001 a Dobricic, Valerijau Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Germany4 aut
7001 a Engelborghs, Sebastiaanu Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Germany; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium4 aut
7001 a Frisoni, Giovanni Bu University of Geneva, Geneva, Switzerland4 aut
7001 a Molinuevo, José Lu Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic-IDIBAPS, Barcelona, Spain; Barcelona Beta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain4 aut
7001 a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwaand
7001 a Popp, Juliusu University Hospital of Lausanne, Lausanne, Switzerland; Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland4 aut
7001 a Martinez-Lage, Pablou CITA-Alzheimer Foundation, San Sebastian, Spain4 aut
7001 a Bertram, Larsu University of Lübeck, Lübeck, Germany4 aut
7001 a Barkhof, Frederiku Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands4 aut
7001 a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn
7001 a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka
7001 a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe
7001 a Streffer, Johannesu Experimental Medicine, Janssen Pharmaceutical Companies, Beerse, Belgium4 aut
7001 a Visser, Pieter Ju Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands; Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands4 aut
7001 a Lovestone, Simonu Department of Psychiatry, University of Oxford, Oxford, UK4 aut
7001 a Legido-Quigley, Cristinau Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut
7102 a Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmarkb Institute of Pharmaceutical Science, King's College London, London, UK; Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK4 org
7730 t Alzheimer's & Dementiad : Elsevierg 15:6, s. 817-827q 15:6<817-827x 1552-5260x 1552-5279
8564 u https://doi.org/10.1016/j.jalz.2019.03.004y Fulltext
8564 u https://doi.org/10.1016/j.jalz.2019.03.004
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79153
8564 8u https://doi.org/10.1016/j.jalz.2019.03.004
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141071627
8564 8u https://gup.ub.gu.se/publication/280954

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