Rise and fall of the new variant of Chlamydia trachomatis in Sweden: mathematical modelling study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: onr:"swepub:oai:DiVA.org:oru-84689" > Rise and fall of th...

1 av 1
Föregående post
Nästa post
Till träfflistan

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		04919naa a2200505 4500
001		oai:DiVA.org:oru-84689
003		SwePub
008		200826s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:uu-402244
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-846892 URI
024	7	a https://doi.org/10.1136/sextrans-2019-0540572 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4022442 URI
040		a (SwePub)orud (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Smid, Joost H.u Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland4 aut
245	1 0	a Rise and fall of the new variant of Chlamydia trachomatis in Sweden :b mathematical modelling study
264		c 2019-10-05
264	1	b BMJ Publishing Group Ltd,c 2020
338		a print2 rdacarrier
500		a Funding Agencies:Swiss National Science Foundation (SNSF) 160320National Institute for Health Research (NIHR) RP-PG-0614-20009
520		a OBJECTIVES: A new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden in 2006. The nvCT has a plasmid deletion, which escaped detection by two nucleic acid amplification tests (Abbott-Roche, AR), which were used in 14 of 21 Swedish counties. The objectives of this study were to assess when and where nvCT emerged in Sweden, the proportion of nvCT in each county and the role of a potential fitness difference between nvCT and co-circulating wild-type strains (wtCT).METHODS: We used a compartmental mathematical model describing the spatial and temporal spread of nvCT and wtCT. We parameterised the model using sexual behaviour data and Swedish spatial and demographic data. We used Bayesian inference to fit the model to surveillance data about reported diagnoses of chlamydia infection in each county and data from four counties that assessed the proportion of nvCT in multiple years.RESULTS: Model results indicated that nvCT emerged in central Sweden (Dalarna, Gävleborg, Västernorrland), reaching a proportion of 1% of prevalent CT infections in late 2002 or early 2003. The diagnostic selective advantage enabled rapid spread of nvCT in the presence of high treatment rates. After detection, the proportion of nvCT decreased from 30%-70% in AR counties and 5%-20% in counties that Becton Dickinson tests, to around 5% in 2015 in all counties. The decrease in nvCT was consistent with an estimated fitness cost of around 5% in transmissibility or 17% reduction in infectious duration.CONCLUSIONS: We reconstructed the course of a natural experiment in which a mutant strain of C. trachomatis spread across Sweden. Our modelling study provides support, for the first time, of a reduced transmissibility or infectious duration of nvCT. This mathematical model improved our understanding of the first nvCT epidemic in Sweden and can be adapted to investigate the impact of future diagnostic escape mutants.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653		a Chlamydia trachomatis
653		a Sweden
653		a basic reproduction number
653		a mathematical model
653		a nucleic acid amplification test
700	1	a Althaus, Christian L.u Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland4 aut
700	1	a Low, Nicolau Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland4 aut
700	1	a Unemo, Magnus,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Laboratory Medicine, Clinical Microbiology4 aut0 (Swepub:oru)muo
700	1	a Herrmann, Björn,d 1955-u Uppsala universitet,Klinisk mikrobiologi4 aut0 (Swepub:uu)bjorherr
710	2	a Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerlandb Institutionen för medicinska vetenskaper4 org
773	0	t Sexually Transmitted Infectionsd : BMJ Publishing Group Ltdg 96:5, s. 375-379q 96:5<375-379x 1368-4973x 1472-3263
856	4	u https://doi.org/10.1136/sextrans-2019-054057y Fulltext
856	4	u https://sti.bmj.com/content/sextrans/96/5/375.full.pdf
856	4	u https://uu.diva-portal.org/smash/get/diva2:1385056/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84689
856	4 8	u https://doi.org/10.1136/sextrans-2019-054057
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-402244

Hitta via bibliotek

Sexually Transmitted Infections (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Smid, Joost H.; Althaus, Christi ...; Low, Nicola; Unemo, Magnus, 1 ...; Herrmann, Björn, ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Klinisk laborato ...

Artiklar i publikationen: Sexually Transmi ...

Av lärosätet: Örebro universitet; Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se