Sökning: onr:"swepub:oai:DiVA.org:oru-88420" > Correlations betwee...
Fältnamn | Indikatorer | Metadata |
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000 | 04974naa a2200457 4500 | |
001 | oai:DiVA.org:oru-88420 | |
003 | SwePub | |
008 | 210112s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-884202 URI |
024 | 7 | a https://doi.org/10.3920/BM2020.00102 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Holster, S.u Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden,Nutrition-Gut-Brain Interactions Research Centre4 aut |
245 | 1 0 | a Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome |
264 | 1 | b Wageningen Academic Publishers,c 2021 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:European Society of Clinical Nutrition and Metabolism (ESPEN) Netherlands Organization for Scientific Research (NWO) | |
520 | a Faecal microbiota transfer (FMT) consists of the infusion of donor faecal material into the intestine of a patient with the aim to restore a disturbed gut microbiota. In this study, it was investigated whether FMT has an effect on faecal microbial composition, its functional capacity, faecal metabolite profiles and their interactions in 16 irritable bowel syndrome (IBS) patients. Faecal samples from eight different time points before and until six months after allogenic FMT (faecal material from a healthy donor) as well as autologous FMT (own faecal material) were analysed by 16S RNA gene amplicon sequencing and gas chromatography coupled to mass spectrometry (GS-MS). The results showed that the allogenic FMT resulted in alterations in the microbial composition that were detectable up to six months, whereas after autologous FMT this was not the case. Similar results were found for the functional profiles, which were predicted from the phylogenetic sequencing data. While both allogenic FMT as well as autologous FMT did not have an effect on the faecal metabolites measured in this study, correlations between the microbial composition and the metabolites showed that the microbe-metabolite interactions seemed to be disrupted after allogenic FMT compared to autologous FMT. This shows that FMT can lead to altered interactions between the gut microbiota and its metabolites in IBS patients. Further research should investigate if and how this affects efficacy of FMT treatments. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
653 | a Colonic microbiota | |
653 | a faecal microbiota transplantation | |
653 | a metabolite profiles | |
653 | a microbe-metabolite interactions | |
700 | 1 | a Repsilber, Dirk,d 1971-u Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre4 aut0 (Swepub:oru)drr |
700 | 1 | a Geng, D.u Faculty of Business, Science and Engineering, School of Science and Technology, Örebro University, Örebro, Sweden,Man-Technology-Environmental Research Centre4 aut |
700 | 1 | a Hyötyläinen, Tuulia,d 1971-u Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environmental Research Centre4 aut0 (Swepub:oru)tihn |
700 | 1 | a Salonen, A.u Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland4 aut |
700 | 1 | a Lindqvist, Carl Mårten,d 1979-u Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre4 aut0 (Swepub:oru)melt |
700 | 1 | a Rajan, Sukithar K,d 1978-u Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centr4 aut0 (Swepub:oru)srrn |
700 | 1 | a de Vos, W. M.u Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Laboratory of Microbiology, Wageningen University and Research Centre, Wageningen, the Netherlands4 aut |
700 | 1 | a Brummer, Robert Jan,d 1957-u Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre4 aut0 (Swepub:oru)rnbr |
700 | 1 | a König, Julia,d 1983-u Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre4 aut0 (Swepub:oru)jkg |
710 | 2 | a Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Swedenb Nutrition-Gut-Brain Interactions Research Centre4 org |
773 | 0 | t Beneficial Microbesd : Wageningen Academic Publishersg 12:1, s. 17-30q 12:1<17-30x 1876-2883x 1876-2891 |
856 | 4 | u https://doi.org/10.3920/BM2020.0010y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88420 |
856 | 4 8 | u https://doi.org/10.3920/BM2020.0010 |
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