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Prognostic Utility ...
Prognostic Utility of the Gleason Grading System Revisions and Histopathological Factors Beyond Gleason Grade.
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- Zelic, Renata (author)
- Karolinska Institutet
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- Giunchi, Francesca (author)
- Pathology Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
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- Fridfeldt, Jonna (author)
- Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Carlsson, Jessica, 1984- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology
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- Davidsson, Sabina, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology
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- Lianas, Luca (author)
- Data-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy
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- Mascia, Cecilia (author)
- Data-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy
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- Zugna, Daniela (author)
- Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, and CPO-Piemonte, Turin, Italy
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- Molinaro, Luca (author)
- Division of Pathology, A.O. Città della Salute e della Scienza Hospital, Turin, Italy
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- Vincent, Per Henrik (author)
- Karolinska Institutet
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- Zanetti, Gianluigi (author)
- Data-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy
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- Andrén, Ove, 1963- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology
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- Richiardi, Lorenzo (author)
- Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, and CPO-Piemonte, Turin, Italy
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- Akre, Olof (author)
- Karolinska Institutet
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- Fiorentino, Michelangelo (author)
- Pathology Service, Maggiore Hospital, University of Bologna, Bologna, Italy
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- Pettersson, Andreas (author)
- Karolinska Institutet
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(creator_code:org_t)
- Dove Medical Press Ltd. 2022
- 2022
- English.
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In: Clinical Epidemiology. - : Dove Medical Press Ltd.. - 1179-1349. ; 14, s. 59-70
- Related links:
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
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- Background: The International Society of Urological Pathology (ISUP) revised the Gleason system in 2005 and 2014. The impact of these changes on prostate cancer (PCa) prognostication remains unclear.Objective: To evaluate if the ISUP 2014 Gleason score (GS) predicts PCa death better than the pre-2005 GS, and if additional histopathological information can further improve PCa death prediction.Patients and Methods: We conducted a case-control study nested among men in the National Prostate Cancer Register of Sweden diagnosed with non-metastatic PCa 1998-2015. We included 369 men who died from PCa (cases) and 369 men who did not (controls). Two uro-pathologists centrally re-reviewed biopsy ISUP 2014 Gleason grading, poorly formed glands, cribriform pattern, comedonecrosis, perineural invasion, intraductal, ductal and mucinous carcinoma, percentage Gleason 4, inflammation, high-grade prostatic intraepithelial neoplasia (HGPIN) and post-atrophic hyperplasia. Pre-2005 GS was back-transformed using i) information on cribriform pattern and/or poorly formed glands and ii) the diagnostic GS from the registry. Models were developed using Firth logistic regression and compared in terms of discrimination (AUC).Results: The ISUP 2014 GS (AUC = 0.808) performed better than the pre-2005 GS when back-transformed using only cribriform pattern (AUC = 0.785) or both cribriform and poorly formed glands (AUC = 0.792), but not when back-transformed using only poorly formed glands (AUC = 0.800). Similarly, the ISUP 2014 GS performed better than the diagnostic GS (AUC = 0.808 vs 0.781). Comedonecrosis (AUC = 0.811), HGPIN (AUC = 0.810) and number of cores with ≥50% cancer (AUC = 0.810) predicted PCa death independently of the ISUP 2014 GS.Conclusion: The Gleason Grading revisions have improved PCa death prediction, likely due to classifying cribriform patterns, rather than poorly formed glands, as Gleason 4. Comedonecrosis, HGPIN and number of cores with ≥50% cancer further improve PCa death discrimination slightly.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Gleason score
- histopathology
- prognosis
- prognostic markers
- prostate cancer
- virtual microscopy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zelic, Renata
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Giunchi, Frances ...
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Fridfeldt, Jonna
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Carlsson, Jessic ...
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Davidsson, Sabin ...
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Lianas, Luca
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Mascia, Cecilia
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Zugna, Daniela
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Molinaro, Luca
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Vincent, Per Hen ...
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Zanetti, Gianlui ...
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Andrén, Ove, 196 ...
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Richiardi, Loren ...
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Akre, Olof
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Fiorentino, Mich ...
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Pettersson, Andr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Clinical Epidemi ...
- By the university
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Örebro University
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Karolinska Institutet