Sökning: onr:"swepub:oai:DiVA.org:su-119245" > Convergent genetic ...
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000 | 10819naa a2202737 4500 | |
001 | oai:DiVA.org:su-119245 | |
003 | SwePub | |
008 | 150803s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:131574811 | |
009 | oai:DiVA.org:uu-260145 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1192452 URI |
024 | 7 | a https://doi.org/10.1016/j.jalz.2014.05.17572 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1315748112 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2601452 URI |
040 | a (SwePub)sud (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jones, Lesley4 aut |
245 | 1 0 | a Convergent genetic and expression data implicate immunity in Alzheimer's disease |
264 | c 2014-12-19 | |
264 | 1 | b Wiley,c 2015 |
338 | a print2 rdacarrier | |
520 | a Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. Methods: The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results: ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 X 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 X 10(-11)), cholesterol transport (P = 2.96 X 10(-9)), and proteasome-ubiquitin activity (P = 1.34 X 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05). Conclusions: The immime response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Alzheimer's disease | |
653 | a Dementia | |
653 | a Neurodegeneration | |
653 | a Immune response | |
653 | a Endocytosis | |
653 | a Cholesterol metabolism | |
653 | a Ubiquitination | |
653 | a Pathway analysis | |
653 | a ALIGATOR | |
653 | a Weighted gene co-expression network analysis | |
700 | 1 | a Lambert, Jean-Charles4 aut |
700 | 1 | a Wang, Li-San4 aut |
700 | 1 | a Choi, Seung-Hoan4 aut |
700 | 1 | a Harold, Denise4 aut |
700 | 1 | a Vedernikov, Alexey4 aut |
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700 | 1 | a Lannfelt, Larsu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)lalan021 |
700 | 1 | a Bis, Joshua C.4 aut |
700 | 1 | a Beecham, Gary W.4 aut |
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700 | 1 | a Martin, Eden R.4 aut |
700 | 1 | a Pastor, Pau4 aut |
700 | 1 | a Schmidt, Reinhold4 aut |
700 | 1 | a Rujescu, Dan4 aut |
700 | 1 | a Dartigues, Jean-Francois4 aut |
700 | 1 | a Mayeux, Richard4 aut |
700 | 1 | a Tzourio, Christophe4 aut |
700 | 1 | a Hofman, Albert4 aut |
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710 | 2 | a Uppsala universitetb Geriatrik4 org |
773 | 0 | t Alzheimer's & Dementiad : Wileyg 11:6, s. 658-671q 11:6<658-671x 1552-5260x 1552-5279 |
856 | 4 | u https://europepmc.org/articles/pmc4672734?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-119245 |
856 | 4 8 | u https://doi.org/10.1016/j.jalz.2014.05.1757 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131574811 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-260145 |
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