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Body Mass Index Pre...
Body Mass Index Predicts Progression of Mild Cognitive Impairment to Dementia
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Cova, Ilaria (author)
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- Clerici, Francesca (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),‘Luigi Sacco' Hospital, University of Milan, Italy
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Maggiore, Laura (author)
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Pomati, Simone (author)
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Cucumo, Valentina (author)
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Ghiretti, Roberta (author)
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Galimberti, Daniela (author)
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Scarpini, Elio (author)
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Mariani, Claudio (author)
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- Caracciolo, Barbara (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden
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(creator_code:org_t)
- 2016-03-31
- 2016
- English.
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In: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 41:3-4, s. 172-180
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Aims: To examine the relationship between body mass index (BMI) and progression to dementia and Alzheimer's disease (AD) in mild cognitive impairment (MCI). Materials and Methods: Two hundred and twenty-eight MCI subjects (mean age 74.04 +/- 6.94 years; 57% female) from a memory clinic were followed for 2.40 +/- 1.58 years. Baseline height and weight were used to calculate the BMI. The main outcome was progression to dementia (DSM-IV criteria) and AD (NINCDS-ADRDA criteria). Cox proportional hazard models were used to assess the longitudinal association of BMI with dementia and AD, adjusting for a comprehensive set of covariates, including vascular risk factors/diseases and neuroimaging profiles. Results: Out of 228 subjects with MCI, 117 (51.3%) progressed to dementia. Eighty-nine (76%) of the incident dementia cases had AD. In both unadjusted and multi-adjusted models, a higher BMI was associated with a reduced risk of dementia (multi-adjusted HR 0.9; 95% CI 0.8-0.9) and AD (multi-adjusted HR 0.9; 95% CI 0.8-0.9). Being underweight increased the risk of all types of dementia (multi-adjusted HR 2.5; 95% CI 1.2-5.1) but was not specifically associated with AD (multi-adjusted HR 2.2; 95% CI 0.9-5.3). Conclusions: BMI predicted progression of MCI to dementia and AD. In particular, a higher BMI was associated with a lower risk of dementia and AD, and underweight was associated with a higher risk of dementia. BMI assessment may improve the prognostic accuracy of MCI in clinical practice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Body mass index
- Dementia
- Mild cognitive impairment
- Weight loss
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cova, Ilaria
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Clerici, Frances ...
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Maggiore, Laura
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Pomati, Simone
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Cucumo, Valentin ...
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Ghiretti, Robert ...
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show more...
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Galimberti, Dani ...
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Scarpini, Elio
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Mariani, Claudio
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Caracciolo, Barb ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Dementia and Ger ...
- By the university
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Stockholm University
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Karolinska Institutet