Sökning: onr:"swepub:oai:DiVA.org:su-131995" > BOLD Variability is...
Fältnamn | Indikatorer | Metadata |
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000 | 04512naa a2200517 4500 | |
001 | oai:DiVA.org:su-131995 | |
003 | SwePub | |
008 | 160705s2016 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-102512 | |
009 | oai:prod.swepub.kib.ki.se:133703891 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1319952 URI |
024 | 7 | a https://doi.org/10.1093/cercor/bhv0292 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1025122 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1337038912 URI |
040 | a (SwePub)sud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Guitart-Masip, Marcu Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University College London, UK4 aut |
245 | 1 0 | a BOLD Variability is Related to Dopaminergic Neurotransmission and Cognitive Aging |
264 | c 2015-03-05 | |
264 | 1 | b Oxford University Press (OUP),c 2016 |
338 | a print2 rdacarrier | |
520 | a Dopamine (DA) losses are associated with various aging-related cognitive deficits. Typically, higher moment-to-moment brain signal variability in large-scale patterns of voxels in neocortical regions is linked to better cognitive performance and younger adult age, yet the physiological mechanisms regulating brain signal variability are unknown. We explored the relationship among adult age, DA availability, and blood oxygen level-dependent (BOLD) signal variability, while younger and older participants performed a spatial working memory (SWM) task. We quantified striatal and extrastriatal DA D1 receptor density with [C-11]SCH23390 and positron emission tomography in all participants. We found that BOLD variability in a neocortical region was negatively related to age and positively related to SWM performance. In contrast, BOLD variability in subcortical regions and bilateral hippocampus was positively related to age and slower responses, and negatively related to D1 density in caudate and dorsolateral prefrontal cortex. Furthermore, BOLD variability in neocortical regions was positively associated with task-related disengagement of the default-mode network, a network whose activation needs to be suppressed for efficient SWM processing. Our results show that age-related DA losses contribute to changes in brain signal variability in subcortical regions and suggest a potential mechanism, by which neocortical BOLD variability supports cognitive performance. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a BOLD variability | |
653 | a cognitive aging | |
653 | a default mode network | |
653 | a dopamine | |
653 | a spatial working memory | |
700 | 1 | a Salami, Alirezau Karolinska Institutet,Umeå universitet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå Center for Functional Brain Imaging, Sweden,Umeå centrum för funktionell hjärnavbildning (UFBI),Aging Research Center, Karolinska Institute, Stockholm, Sweden4 aut0 (Swepub:umu)alsa0014 |
700 | 1 | a Garrett, Douglas4 aut |
700 | 1 | a Rieckmann, Annau Center for Brain Science, Harvard University, Cambridge, USA4 aut0 (Swepub:umu)anri0051 |
700 | 1 | a Lindenberger, Ulman4 aut |
700 | 1 | a Bäckman, Larsu Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
710 | 2 | a Stockholms universitetb Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 org |
773 | 0 | t Cerebral Cortexd : Oxford University Press (OUP)g 26:5, s. 2074-2083q 26:5<2074-2083x 1047-3211x 1460-2199 |
856 | 4 | u https://pure.mpg.de/pubman/item/item_2282709_8/component/file_2289954/id10001156.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-131995 |
856 | 4 8 | u https://doi.org/10.1093/cercor/bhv029 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102512 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133703891 |
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