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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005766naa a2200649 4500
001oai:DiVA.org:su-139446
003SwePub
008170223s2016 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:c3feeeca-f060-4470-bc81-abb6512ebfb8
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1394462 URI
0247 a https://doi.org/10.1161/JAHA.116.0045032 DOI
0247 a https://lup.lub.lu.se/record/c3feeeca-f060-4470-bc81-abb6512ebfb82 URI
040 a (SwePub)sud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kjellqvist, Sanelau Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)skjel
2451 0a Identification of Shared and Unique Serum Lipid Profiles in Diabetes Mellitus and Myocardial Infarction
264 1c 2016
338 a print2 rdacarrier
520 a Background-Diabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown. Methods and Results-We used shotgun mass spectrometry to determine serum levels of 255 molecular lipids in 316 controls, 171 DM, and 99 myocardial infarction (MI) events from a cohort derived from the Malmo Diet and Cancer study. Orthogonal projections to latent structures analyses were conducted between the lipids and clinical parameters describing DM or MI. Fatty acid desaturases (FADS) and elongation of very long chain fatty acid protein 5 (ELOVL5) activities were estimated by calculating product to precursor ratios of polyunsaturated fatty acids in complex lipids. FADS genotypes encoding these desaturases were then tested for association with lipid levels and ratios. Differences in the levels of lipids belonging to the phosphatidylcholine and triacylglyceride (TAG) classes contributed the most to separating DM from controls. TAGs also played a dominating role in discriminating MI from controls. Levels of C18:2 fatty acids in complex lipids were lower both in DM and MI versus controls (DM, P=0.004; MI, P=6.0E-06) at least due to an acceleration in the metabolic flux from C18: 2 to C20:4 (eg, increased estimated ELOVL5: DM, P=0.02; MI, P=0.04, and combined elongase-desaturase activities: DM, P=3.0E-06; MI, P=2.0E-06). Minor allele carriers of FADS genotypes were associated with increased levels of C18: 2 (P <= 0.007) and lower desaturase activity (P <= 0.002). Conclusions-We demonstrate a possible relationship between decreased levels of C18: 2 in complex lipids and DM or MI. We thereby highlight the importance of molecular lipids in the pathogenesis of both diseases.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a diabetes mellitus
653 a fatty acid desaturase
653 a genotype
653 a lipid metabolites
653 a myocardial infarction
653 a Diabetes mellitus
653 a Fatty acid desaturase
653 a Genotype
653 a Lipid metabolites
653 a Myocardial infarction
7001 a Klose, Christianu Lipotype GmbH4 aut
7001 a Surma, Michal A.u Lipotype GmbH4 aut
7001 a Hindy, Georgeu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)med-ghu
7001 a Mollet, Ines G.4 aut
7001 a Johansson, Annau Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut
7001 a Chavaux, Patricku Aix-Marseille University4 aut
7001 a Gottfries, Johanu University of Gothenburg4 aut
7001 a Simons, Kaiu Lipotype GmbH4 aut
7001 a Melander, Olleu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
7001 a Fernandez, Célineu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)medk-cfe
7102 a Stockholms universitetb Institutionen för biokemi och biofysik4 org
7730 t Journal of the American Heart Associationg 5:12q 5:12x 2047-9980
8564 u https://doi.org/10.1161/JAHA.116.004503y Fulltext
8564 u http://dx.doi.org/10.1161/JAHA.116.004503x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-139446
8564 8u https://doi.org/10.1161/JAHA.116.004503
8564 8u https://lup.lub.lu.se/record/c3feeeca-f060-4470-bc81-abb6512ebfb8

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