Sökning: onr:"swepub:oai:DiVA.org:su-169092" > Discovery of glycer...
Fältnamn | Indikatorer | Metadata |
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000 | 03302naa a2200529 4500 | |
001 | oai:DiVA.org:su-169092 | |
003 | SwePub | |
008 | 190618s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1690922 URI |
024 | 7 | a https://doi.org/10.1038/s41589-019-0251-42 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Edgar, Rebecca J.4 aut |
245 | 1 0 | a Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides |
264 | c 2019-04-01 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
338 | a print2 rdacarrier | |
520 | a Cell wall glycopolymers on the surface of Gram-positive bacteria are fundamental to bacterial physiology and infection biology. Here we identify gacH, a gene in the Streptococcus pyogenes group A carbohydrate (GAC) biosynthetic cluster, in two independent transposon library screens for its ability to confer resistance to zinc and susceptibility to the bactericidal enzyme human group IIA-secreted phospholipase A(2). Subsequent structural and phylogenetic analysis of the GacH extracellular domain revealed that GacH represents an alternative class of glycerol phosphate transferase. We detected the presence of glycerol phosphate in the GAC, as well as the serotype c carbohydrate from Streptococcus mutans, which depended on the presence of the respective gacH homologs. Finally, nuclear magnetic resonance analysis of GAC confirmed that glycerol phosphate is attached to approximately 25% of the GAC N-acetylglucosamine side-chains at the C6 hydroxyl group. This previously unrecognized structural modification impacts host-pathogen interaction and has implications for vaccine design. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
700 | 1 | a van Hensbergen, Vincent P.4 aut |
700 | 1 | a Ruda, Alessandrou Stockholms universitet,Institutionen för organisk kemi4 aut0 (Swepub:su)alru3031 |
700 | 1 | a Turner, Andrew G.4 aut |
700 | 1 | a Deng, Pan4 aut |
700 | 1 | a Le Breton, Yoann4 aut |
700 | 1 | a El-Sayed, Najib M.4 aut |
700 | 1 | a Belew, Ashton T.4 aut |
700 | 1 | a McIver, Kevin S.4 aut |
700 | 1 | a McEwan, Alastair G.4 aut |
700 | 1 | a Morris, Andrew J.4 aut |
700 | 1 | a Lambeau, Gérard4 aut |
700 | 1 | a Walker, Markj4 aut |
700 | 1 | a Rush, Jeffrey S.4 aut |
700 | 1 | a Korotkov, Konstantin4 aut |
700 | 1 | a Widmalm, Göranu Stockholms universitet,Institutionen för organisk kemi4 aut0 (Swepub:su)gw |
700 | 1 | a van Sorge, Nina M.4 aut |
700 | 1 | a Korotkova, Natalia4 aut |
710 | 2 | a Stockholms universitetb Institutionen för organisk kemi4 org |
773 | 0 | t Nature Chemical Biologyd : Springer Science and Business Media LLCg 15:5, s. 463-+q 15:5<463-+x 1552-4450x 1552-4469 |
856 | 4 | u https://www.nature.com/articles/s41589-019-0251-4.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-169092 |
856 | 4 8 | u https://doi.org/10.1038/s41589-019-0251-4 |
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