onr:"swepub:oai:DiVA.org:su-173176"
Sökning: onr:"swepub:oai:DiVA.org:su-173176" > Effects of Leachate...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03668naa a2200397 4500 | |
| 001 | oai:DiVA.org:su-173176 | |
| 003 | SwePub | |
| 008 | 190918s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1731762 URI |
| 024 | 7 | a https://doi.org/10.1021/acs.est.9b024002 DOI |
| 040 | a (SwePub)su | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Rummel, Christoph D.4 aut |
| 245 | 1 0 | a Effects of Leachates from UV-Weathered Microplastic in Cell-Based Bioassays |
| 264 | c 2019-06-30 | |
| 264 | 1 | b American Chemical Society (ACS),c 2019 |
| 338 | a print2 rdacarrier | |
| 520 | a Standard ecotoxicological testing of microplastic does not provide insight into the influence that environmental weathering by, e.g., UV light has on related effects. In this study, we leached chemicals from plastic into artificial seawater during simulated UV-induced weathering. We tested largely additive-free preproduction polyethylene, polyethylene terephthalate, polypropylene, and polystyrene and two types of plastic obtained from electronic equipment as positive controls. Leachates were concentrated by solid-phase extraction and dosed into cell-based bioassays that cover (i) cytotoxicity; (ii) activation of metabolic enzymes via binding to the arylhydrocarbon receptor (AhR) and the peroxisome proliferator-activated receptor (PPAR gamma); (iii) specific, receptor-mediated effects (estrogenicity, ER alpha); and (iv) adaptive response to oxidative stress (AREc32). LC-HRMS analysis was used to identify possible chain-scission products of polymer degradation, which were then tested in AREc32 and PPAR gamma. Explicit activation of all assays by the positive controls provided proof-of-concept of the experimental setup to demonstrate effects of chemicals liberated during weathering. All plastic leachates activated the oxidative stress response, in most cases with increased induction by UV-treated samples compared to dark controls. For PPAR gamma, polyethylene-specific effects were partially explained by the detected dicarboxylic acids. Since the preproduction plastic showed low effects often in the range of the blanks future studies should investigate implications of weathering on end consumer products containing additives. | |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Naturresursteknik0 (SwePub)2072 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Environmental Engineering0 (SwePub)2072 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Geovetenskap och miljövetenskap0 (SwePub)1052 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Earth and Related Environmental Sciences0 (SwePub)1052 hsv//eng |
| 700 | 1 | a Escher, Beate4 aut |
| 700 | 1 | a Sandblom, Oskaru Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)ossa1616 |
| 700 | 1 | a Plassmann, Merle M.u Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)mples |
| 700 | 1 | a Arp, Hans Peter H.4 aut |
| 700 | 1 | a MacLeod, Matthewu Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)mmacl |
| 700 | 1 | a Jahnke, Annika4 aut |
| 710 | 2 | a Stockholms universitetb Institutionen för miljövetenskap och analytisk kemi4 org |
| 773 | 0 | t Environmental Science and Technologyd : American Chemical Society (ACS)g 53:15, s. 9214-9223q 53:15<9214-9223x 0013-936Xx 1520-5851 |
| 856 | 4 | u https://pubs.acs.org/doi/pdf/10.1021/acs.est.9b02400 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-173176 |
| 856 | 4 8 | u https://doi.org/10.1021/acs.est.9b02400 |
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