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The basic machineries for mitochondrial protein quality control
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- Vazquez-Calvo, Carmela (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Suhm, Tamara (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Büttner, Sabrina (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria
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- (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
- In: Mitochondrion (Amsterdam. Print). - : Elsevier BV. - 1567-7249 .- 1872-8278. ; 50, s. 121-131
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Mitochondria play pivotal roles in cellular energy metabolism, the synthesis of essential biomolecules and the regulation of cell death and aging. The proper folding, unfolding and degradation of the many proteins active within mitochondria is surveyed by the mitochondrial quality control machineries. Here, we describe the principal components of the mitochondrial quality control system and recent developments in the elucidation of the molecular mechanisms maintaining a functional mitochondrial proteome.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Mitochondria
- Proteostasis
- Quality control
- Proteases
- Chaperones
- Mitophagy
- Aggregates
Publication and Content Type
- ref (subject category)
- art (subject category)
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