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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04198naa a2200457 4500 | |
| 001 | oai:DiVA.org:su-183146 | |
| 003 | SwePub | |
| 008 | 200702s2020 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:143676768 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1831462 URI |
| 024 | 7 | a https://doi.org/10.1016/j.resuscitation.2020.02.0322 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1436767682 URI |
| 040 | a (SwePub)sud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Rysz, Susanneu Karolinska Institutet4 aut |
| 245 | 1 0 | a The effect of levosimendan on survival and cardiac performance in an ischemic cardiac arrest model - A blinded randomized placebo -controlled study in swine |
| 264 | 1 | b Elsevier BV,c 2020 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Survival after out-of-hospital cardiac arrest remains poor. Levosimendan could be a new intervention in this setting. Therefore, we conducted a blinded, placebo controlled randomized study investigating the effects of levosimendan on survival and cardiac performance in an ischemic cardiac arrest model in swine. Methods: Twenty-four anesthetised swines underwent experimentally-induced acute myocardial infarction and ventricular fibrillation. At the start of CPR, a bolus dose of levosimendan (12 μg kg-1) or placebo was given followed by a 24-h infusion (0.2 μg kg-1 min-1) after return of spontaneously circulation. Animals were evaluated by risk of death, post-resuscitation hemodynamics and infarction size by magnetic resonance imaging (MRI) up to 32 h post arrest. Results: Spontaneous circulation was restored in all (12/12) animals in the levosimendan group compared to two thirds (8/12) in the placebo group (P = 0.09). Protocol survival was higher for the levosimendan group (P = 0.02) with an estimated 88% lower risk of death compared to placebo (hazard ratio [95% confidence interval] 0.12 [0.01-0.96], P = 0.046). Cardiac output (CO) recovered 40% faster during the first hour of the intensive care period for the levosimendan group (difference 0.13 [0.01-0.26] L min-1P = 0.04). The placebo group required higher inotropic support during the intensive care period which masked an even bigger recovery in CO in the levosimendan group (58%). The MRI showed no difference in myocardial scar size or in myocardial area at risk. Conclusions: Levosimendan given intra-arrest and during the first 24-h of post-resuscitation care improved survival and cardiac performance in this ischemic cardiac arrest model. Institutional Protocol Number; KERIC 5.2.18-14933. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 700 | 1 | a Lundberg, Johanu Karolinska Institutet4 aut |
| 700 | 1 | a Nordberg, Peru Karolinska Institutet4 aut |
| 700 | 1 | a Eriksson, Helenu Stockholms universitet,Sociologiska institutionen4 aut0 (Swepub:su)heler |
| 700 | 1 | a Wieslander, Bjornu Karolinska Institutet4 aut |
| 700 | 1 | a Lundin, Magnusu Karolinska Institutet4 aut |
| 700 | 1 | a Fyrdahl, Alexanderu Karolinska Institutet4 aut |
| 700 | 1 | a Pernow, Johnu Karolinska Institutet4 aut |
| 700 | 1 | a Ugander, Martinu Karolinska Institutet4 aut |
| 700 | 1 | a Djarv, Thereseu Karolinska Institutet4 aut |
| 700 | 1 | a Fagerlund, Malin Jonssonu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Sociologiska institutionen4 org |
| 773 | 0 | t Resuscitationd : Elsevier BVg 150, s. 113-120q 150<113-120x 0300-9572x 1873-1570 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-183146 |
| 856 | 4 8 | u https://doi.org/10.1016/j.resuscitation.2020.02.032 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143676768 |
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