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PET imaging of cort...
PET imaging of cortical 11C-nicotine binding correlates with the cognitive function of attention in Alzheimer´s disease.
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Kadir, Ahmadul (författare)
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- Almkvist, Ove (författare)
- Karolinska Institutet,Stockholms universitet,Psykologiska institutionen
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- Wall, Anders (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Långström, Bengt (författare)
- Uppsala universitet,Institutionen för biokemi och organisk kemi
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- Nordberg, Agneta (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2006-07-11
- 2006
- Engelska.
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Ingår i: Psychopharmacology. - : Springer Science and Business Media LLC. - 0033-3158 .- 1432-2072. ; 188:4, s. 509-520
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Rationale: Patients suffering from Alzheimer's disease (AD) experience a marked reduction in cortical nicotinic acetylcholine receptors (nAChRs). In particular, selective loss of the α-sub-4β-sub-2 nAChR subtype was observed in postmortem AD brain tissue. The α-sub-4 and α-sub-7 nAChR subunits were suggested to play an important role in cognitive function. Positron emission tomography (PET) has so far been used to visualize neuronal nAChRs in vivo by 11C-nicotine binding. Objectives: To investigate the relationship between measures of cognitive function and in vivo 11C-nicotine binding in mild AD brain as assessed by PET. Materials and methods: Twenty-seven patients with mild AD were recruited in this study. A dual tracer model with administration of 1-sup-5O-water for regional cerebral blood flow and (S)(-)11C-nicotine was used to assess nicotine binding sites in the brain by PET. Cognitive function was assessed using neuropsychological tests of global cognition, episodic memory, attention, and visuospatial ability. Results: Mean cortical 11C-nicotine binding significantly correlated with the results of attention tests (r = -0.44 and p = 0.02) and Trail Making Test A (TMT-A) (r = 0.42 and p = 0.03)]. No significant correlation was observed between 11C-nicotine binding and the results of tests of episodic memory or visuospatial ability. Regional analysis showed that 11C-nicotine binding in the frontal and parietal cortex, which are the main areas for attention, correlated significantly with the Digit Symbol test and TMT-A results. Conclusion: Cortical nicotinic receptors in vivo in mild AD patients are robustly associated with the cognitive function of attention.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- PET
- Alzheimer’s disease
- attention
- cognition
- nicotine
- brain
- tomography
- Psychology
- Psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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