onr:"swepub:oai:DiVA.org:su-210357"
Search: onr:"swepub:oai:DiVA.org:su-210357" > Advanced Molecular ...
- 1 of 1
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04030naa a2200721 4500 | |
| 001 | oai:DiVA.org:su-210357 | |
| 003 | SwePub | |
| 008 | 221012s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2103572 URI |
| 024 | 7 | a https://doi.org/10.1021/jacsau.2c002202 DOI |
| 040 | a (SwePub)su | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Weil, Tatjana4 aut |
| 245 | 1 0 | a Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses |
| 264 | c 2022-09-06 | |
| 264 | 1 | b American Chemical Society (ACS),c 2022 |
| 338 | a print2 rdacarrier | |
| 520 | a The COVID-19 pandemic caused by SARS-CoV-2 presents a global health emergency. Therapeutic options against SARS-CoV-2 are still very limited but urgently required. Molecular tweezers are supramolecular agents that destabilize the envelope of viruses resulting in a loss of viral infectivity. Here, we show that first-generation tweezers, CLR01 and CLR05, disrupt the SARS-CoV-2 envelope and abrogate viral infectivity. To increase the antiviral activity, a series of 34 advanced molecular tweezers were synthesized by insertion of aliphatic or aromatic ester groups on the phosphate moieties of the parent molecule CLR01. A structure-activity relationship study enabled the identification of tweezers with a markedly enhanced ability to destroy lipid bilayers and to suppress SARS-CoV-2 infection. Selected tweezer derivatives retain activity in airway mucus and inactivate the SARS-CoV-2 wildtype and variants of concern as well as respiratory syncytial, influenza, and measles viruses. Moreover, inhibitory activity of advanced tweezers against respiratory syncytial virus and SARS-CoV-2 was confirmed in mice. Thus, potentiated tweezers are broad-spectrum antiviral agents with great prospects for clinical development to combat highly pathogenic viruses. | |
| 650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
| 653 | a broad-spectrum antivirals | |
| 653 | a SARS-CoV-2 | |
| 653 | a RSV | |
| 653 | a molecular tweezers | |
| 653 | a respiratory viruses | |
| 700 | 1 | a Kirupakaran, Abbna4 aut |
| 700 | 1 | a Le, My-Hue4 aut |
| 700 | 1 | a Rebmann, Philipp4 aut |
| 700 | 1 | a Mieres-Perez, Joel4 aut |
| 700 | 1 | a Issmail, Leila4 aut |
| 700 | 1 | a Conzelmann, Carina4 aut |
| 700 | 1 | a Müller, Janis A.4 aut |
| 700 | 1 | a Rauch, Lena4 aut |
| 700 | 1 | a Gilg, Andrea4 aut |
| 700 | 1 | a Wettstein, Lukas4 aut |
| 700 | 1 | a Groß, Rüdiger4 aut |
| 700 | 1 | a Read, Clarissa4 aut |
| 700 | 1 | a Bergner, Tim4 aut |
| 700 | 1 | a Axberg Pålsson, Sandra,d 1991-u Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)sapa8421 |
| 700 | 1 | a Uhlig, Nadja4 aut |
| 700 | 1 | a Eberlein, Valentina4 aut |
| 700 | 1 | a Wöll, Heike4 aut |
| 700 | 1 | a Klärner, Frank-Gerrit4 aut |
| 700 | 1 | a Stenger, Steffen4 aut |
| 700 | 1 | a Kümmerer, Beate M.4 aut |
| 700 | 1 | a Streeck, Hendrik4 aut |
| 700 | 1 | a Fois, Giorgio4 aut |
| 700 | 1 | a Frick, Manfred4 aut |
| 700 | 1 | a Braubach, Peter4 aut |
| 700 | 1 | a Spetz, Anna-Lena,d 1947-u Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)aspet |
| 700 | 1 | a Grunwald, Thomas4 aut |
| 700 | 1 | a Shorter, James4 aut |
| 700 | 1 | a Sanchez-Garcia, Elsa4 aut |
| 700 | 1 | a Schrader, Thomas4 aut |
| 700 | 1 | a Münch, Jan4 aut |
| 710 | 2 | a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org |
| 773 | 0 | t JACS Aud : American Chemical Society (ACS)g 2:9, s. 2187-2202q 2:9<2187-2202x 2691-3704 |
| 856 | 4 | u https://doi.org/10.1021/jacsau.2c00220y Fulltext |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-210357 |
| 856 | 4 8 | u https://doi.org/10.1021/jacsau.2c00220 |
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Weil, Tatjana
- Kirupakaran, Abb ...
- Le, My-Hue
- Rebmann, Philipp
- Mieres-Perez, Jo ...
- Issmail, Leila
- show more...
- Conzelmann, Cari ...
- Müller, Janis A.
- Rauch, Lena
- Gilg, Andrea
- Wettstein, Lukas
- Groß, Rüdiger
- Read, Clarissa
- Bergner, Tim
- Axberg Pålsson, ...
- Uhlig, Nadja
- Eberlein, Valent ...
- Wöll, Heike
- Klärner, Frank-G ...
- Stenger, Steffen
- Kümmerer, Beate ...
- Streeck, Hendrik
- Fois, Giorgio
- Frick, Manfred
- Braubach, Peter
- Spetz, Anna-Lena ...
- Grunwald, Thomas
- Shorter, James
- Sanchez-Garcia, ...
- Schrader, Thomas
- Münch, Jan
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Chemical Science ...
- Articles in the publication
- JACS Au
- By the university
- Stockholm University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
