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Random point mutati...
Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
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Edgar, Daniel (author)
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- Shabalina, Irina (author)
- Stockholms universitet,Avdelningen för fysiologi
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Camara, Yolanda (author)
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- Wredenberg, Anna (author)
- Karolinska Institutet
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Calvaruso, Maria Antonietta (author)
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Nijtmans, Leo (author)
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- Nedergaard, Jan (author)
- Stockholms universitet,Avdelningen för fysiologi
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- Cannon, Barbara (author)
- Stockholms universitet,Avdelningen för fysiologi
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- Larsson, Nils-Göran (author)
- Karolinska Institutet
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- Trifunovic, Aleksandra (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Cell metabolism. - : Elsevier BV. - 1932-7420 .- 1550-4131. ; 10:2, s. 131-8
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http://www.cell.com/...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The mtDNA mutator mice have high levels of point mutations and linear deletions of mtDNA causing a progressive respiratory chain dysfunction and a premature aging phenotype. We have now performed molecular analyses to determine the mechanism whereby these mtDNA mutations impair respiratory chain function. We report that mitochondrial protein synthesis is unimpaired in mtDNA mutator mice consistent with the observed minor alterations of steady-state levels of mitochondrial transcripts. These findings refute recent claims that circular mtDNA molecules with large deletions are driving the premature aging phenotype. We further show that the stability of several respiratory chain complexes is severely impaired despite normal synthesis of the corresponding mtDNA-encoded subunits. Our findings reveal a mechanism for induction of aging phenotypes by demonstrating a causative role for amino acid substitutions in mtDNA-encoded respiratory chain subunits, which, in turn, leads to decreased stability of the respiratory chain complexes and respiratory chain deficiency.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Physiology
- Fysiologi
- fysiologi
- Physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Edgar, Daniel
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Shabalina, Irina
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Camara, Yolanda
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Wredenberg, Anna
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Calvaruso, Maria ...
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Nijtmans, Leo
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show more...
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Nedergaard, Jan
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Cannon, Barbara
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Larsson, Nils-Gö ...
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Trifunovic, Alek ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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Cell metabolism
- By the university
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Stockholm University
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Karolinska Institutet