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Sökning: onr:"swepub:oai:DiVA.org:su-53029" > Polybrominated diph...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003351naa a2200385 4500
001oai:DiVA.org:su-53029
003SwePub
008110119s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-530292 URI
0247 a https://doi.org/10.1186/1476-069X-10-12 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hertz-Picciotto, I.4 aut
2451 0a Polybrominated dipheny ehters in relation to autism and developmental delay :b A case-control study
264 1c 2011
338 a print2 rdacarrier
520 a Background: Polybrominated diphenyl ethers (PBDEs) are flame retardants used widely and in increasing amounts in the U.S. over the last few decades. PBDEs and their metabolites cross the placenta and studies in rodents demonstrate neurodevelopmental toxicity from prenatal exposures. PBDE exposures occur both via breastfeeding and hand-to-mouth activities in small children. Methods: Participants were 100 children from the CHARGE (CHildhood Autism Risk from Genetics and the Environment) Study, a case-control epidemiologic investigation of children with autism/autism spectrum disorder, with developmental delay and from the general population. Diagnoses of autism were confirmed by the Autism Diagnostic Observation Schedule and Autism Diagnostic Inventory-Revised, and of developmental delay using the Mullen's Scales of Early Learning and the Vineland Adaptive Behavior Scales. Typically developing controls were those with no evidence of delay, autism, or autism spectrum disorder. Eleven PBDE congeners were measured by gas chromatography/mass spectrometry from serum specimens collected after children were assessed. Logistic regression was used to evaluate the association between plasma PBDEs and autism. Results: Children with autism/autism spectrum disorder and developmental delay were similar to typically developing controls for all PBDE congeners, but levels were high for all three groups. Conclusions: Plasma samples collected post-diagnosis in this study may not represent early life exposures due to changes in diet and introduction of new household products containing PBDEs. Studies with direct measurements of prenatal or infant exposures are needed to assess the possible causal role for these compounds in autism spectrum disorders.  
650 7a NATURVETENSKAPx Geovetenskap och miljövetenskapx Miljövetenskap0 (SwePub)105022 hsv//swe
650 7a NATURAL SCIENCESx Earth and Related Environmental Sciencesx Environmental Sciences0 (SwePub)105022 hsv//eng
653 a Environmental chemistry
653 a Miljökemi
7001 a Bergman, Åkeu Stockholms universitet,Avdelningen för miljökemi4 aut0 (Swepub:su)alb
7001 a Fängström, Brittau Stockholms universitet,Avdelningen för miljökemi4 aut
7001 a Rose, M. B.4 aut
7001 a Krakowiak, P.4 aut
7001 a Pessah, I. N.4 aut
7001 a Hansen, R. L.4 aut
7001 a Bennett, D. H.4 aut
7102 a Stockholms universitetb Avdelningen för miljökemi4 org
7730 t Environmental Healthg 10, s. 1-q 10<1-x 1476-069X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-53029
8564 8u https://doi.org/10.1186/1476-069X-10-1

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