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Prostate alpha/beta revisited - an analysis of clinical results from 14168 patients
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- Dasu, Alexandru (author)
- Linköpings universitet,Östergötlands Läns Landsting,Radiofysikavdelningen US,Hälsouniversitetet,Avdelningen för radiologiska vetenskaper
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- Toma-Dasu, Iuliana (author)
- Stockholms universitet,Fysikum,Karolinska Institutet, Sweden,Stockholm University and Karolinska Institutet
- (creator_code:org_t)
- 2012
- 2012
- English.
- In: Acta Oncologica. - 0284-186X .- 1651-226X. ; 51:8, s. 963-974
- Research review (peer-reviewed)
Abstract
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- Purpose: To determine the dose response parameters and the fractionation sensitivity of prostate tumours from clinical results of patients treated with external beam radiotherapy.Material and methods: The study was based on 5-year biochemical results from 14168 patients treated with external beam radiotherapy. Treatment data from 11330 patients treated with conventional fractionation have been corrected for overall treatment time and fitted with a logit equation. The results have been used to determine the optimum α/β values that minimise differences in predictions from 2838 patients treated with hypofractionated schedules.Results: Conventional fractionation data yielded logit dose response parameters for all risk groups and for all definitions of biochemical failures. The analysis of hypofractionation data led to very low α/β values (1-1.7 Gy) in all mentioned cases. Neglecting the correction for overall treatment time has little impact on the derivation of α/β values for prostate cancers.Conclusions: These results indicate that the high fractionation sensitivity is an intrinsic property of prostate carcinomas and they support the use of hypofractionation to increase the therapeutic gain for these tumours.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Prostate cancer
- radiotherapy
- alpha/beta
- LQ model
- Radiation Physics
- radiofysik
- Oncology
- onkologi
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