Genetic Polymorphisms in Monoamine Systems and Outcome of Cognitive Behavior Therapy for Social Anxiety Disorder

Andersson, Evelyn (author): Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden

Rück, Christian (author): Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden

Lavebratt, Catharina (author): Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden

Hedman, Erik (author): Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden

Schalling, Martin (author): Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden

Lindefors, Nils (author): Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden

Eriksson, Elias, 1956 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Sahlgrenska Academy, University of Gothenburg, Sweden

Carlbring, Per (author): Stockholms universitet,Psykologiska institutionen,Stockholm University, Sweden

Andersson, Gerhard, 1966- (author): Linköpings universitet,Karolinska Institutet,Psykologi,Filosofiska fakulteten,Karolinska Institutet, Stockholm, Sweden,Internet, health and clinical psychology research group

Furmark, Tomas (author): Uppsala universitet,Institutionen för psykologi,Uppsala University, Sweden

(creator_code:org_t)

Related links:: https://doi.org/10.1...; show more...; https://journals.plo...; https://uu.diva-port... (primary) (Raw object); https://liu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; https://gup.ub.gu.se...; https://urn.kb.se/re...; show less...

Abstract Subject headings

ObjectiveThe role of genetics for predicting the response to cognitive behavior therapy (CBT) for social anxiety disorder (SAD) has only been studied in one previous investigation. The serotonin transporter (5-HTTLPR), the catechol-o-methyltransferase (COMT) val158met, and the tryptophan hydroxylase-2 (TPH2) G-703Tpolymorphisms are implicated in the regulation of amygdala reactivity and fear extinction and therefore might be of relevance for CBT outcome. The aim of the present study was to investigate if these three gene variants predicted response to CBT in a large sample of SAD patients.MethodParticipants were recruited from two separate randomized controlled CBT trials (trial 1: n = 112, trial 2: n = 202). Genotyping were performed on DNA extracted from blood or saliva samples. Effects were analyzed at follow-up (6 or 12 months after treatment) for both groups and for each group separately at post-treatment. The main outcome measure was the Liebowitz Social Anxiety Scale Self-Report.ResultsAt long-term follow-up, there was no effect of any genotype, or gene × gene interactions, on treatment response. In the subsamples, there was time by genotype interaction effects indicating an influence of the TPH2 G-703T-polymorphism on CBT short-term response, however the direction of the effect was not consistent across trials.ConclusionsNone of the three gene variants, 5-HTTLPR, COMTval158met and TPH2 G-703T, was associated with long-term response to CBT for SAD.

SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
SOCIAL SCIENCES -- Psychology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
SAMHÄLLSVETENSKAP -- Psykologi -- Tillämpad psykologi (hsv//swe)
SOCIAL SCIENCES -- Psychology -- Applied Psychology (hsv//eng)

By the author/editor: Andersson, Evely ...; Rück, Christian; Lavebratt, Catha ...; Hedman, Erik; Schalling, Marti ...; Lindefors, Nils; show more...; Eriksson, Elias, ...; Carlbring, Per; Andersson, Gerha ...; Furmark, Tomas; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

By the university: Stockholm University; Uppsala University; Karolinska Institutet; University of Gothenburg; Linköping University

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.