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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02464naa a2200421 4500 | |
| 001 | oai:DiVA.org:umu-103715 | |
| 003 | SwePub | |
| 008 | 150528s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1037152 URI |
| 024 | 7 | a https://doi.org/10.1016/j.molstruc.2015.03.0252 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Davidovich, P. B.4 aut |
| 245 | 1 0 | a Synthesis, structure, biochemical, and docking studies of a new dinitrosyl iron complex [Fe-2(mu-SC4H3SCH2)(2)(NO)(4)] |
| 264 | 1 | b Elsevier BV,c 2015 |
| 338 | a print2 rdacarrier | |
| 520 | a A new dinitrosyl iron complex of binuclear structure [Fe-2(mu-S-2-methylthiophene)(2)(NO)(4)] was first synthesized and structurally characterized by XRD and theoretical methods. Using caspase-3 as an example it was shown that [Fe-2(mu-S-2-methylthiophene)(2)(NO)(4)] and its analog [Fe-2(mu-S-2-methylfurane)(2)(NO)(4)] can inhibit the action of active site cysteine proteins; the difference in inhibitory activity was explained by molecular docking studies. Biochemical and in silico studies give grounds that the biological activity of dinitrosyl iron complexes is a mu-SR bridging ligand structure function. Thus the rational design strategy of [Fe-2(mu-SR)(2)(NO)(4)] complexes can be applied to make NO prodrugs with high affinity to therapeutically significant targets involved in cancer and inflammation. | |
| 650 | 7 | a NATURVETENSKAPx Kemix Fysikalisk kemi0 (SwePub)104022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Physical Chemistry0 (SwePub)104022 hsv//eng |
| 653 | a Dinitrosyl iron complex | |
| 653 | a X-ray | |
| 653 | a DFT | |
| 653 | a NO donors | |
| 653 | a Caspase-3 inhibition | |
| 653 | a Docking | |
| 700 | 1 | a Fischer, A. I.4 aut |
| 700 | 1 | a Korchagin, D. V.4 aut |
| 700 | 1 | a Panchuk, V. V.4 aut |
| 700 | 1 | a Shchukarev, Andrey V.u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)ansh0001 |
| 700 | 1 | a Garabadzhiu, A. V.4 aut |
| 700 | 1 | a Belyaev, A. N.4 aut |
| 710 | 2 | a Umeå universitetb Kemiska institutionen4 org |
| 773 | 0 | t Journal of Molecular Structured : Elsevier BVg 1092, s. 137-142q 1092<137-142x 0022-2860x 1872-8014 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103715 |
| 856 | 4 8 | u https://doi.org/10.1016/j.molstruc.2015.03.025 |
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