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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02933naa a2200361 4500 | |
| 001 | oai:DiVA.org:umu-121443 | |
| 003 | SwePub | |
| 008 | 160602s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1214432 URI |
| 024 | 7 | a https://doi.org/10.1038/srep258702 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Chen, Jialinu Umeå universitet,Anatomi4 aut0 (Swepub:umu)jich0005 |
| 245 | 1 0 | a Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt |
| 264 | c 2016-05-13 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2016 |
| 338 | a electronic2 rdacarrier | |
| 520 | a The migration of limbal epithelial stem cells is important for the homeostasis and regeneration of corneal epithelium. Ciliary neurotrophic factor (CNTF) has been found to promote corneal epithelial wound healing by activating corneal epithelial stem/progenitor cells. However, the possible effect of CNTF on the migration of corneal epithelial stem/progenitor cells is not clear. This study found the expression of CNTF in mouse corneal epithelial stem/progenitor cells (TKE2) to be up-regulated after injury, on both gene and protein level. CNTF promoted migration of TKE2 in a dose-dependent manner and the peak was seen at 10 ng/ml. The phosphorylation level of Akt (p-Akt), and the expression of MMP3 and MMP14, were up-regulated after CNTF treatment both in vitro and in vivo. Akt and MMP3 inhibitor treatment delayed the migration effect by CNTF. Finally, a decreased expression of MMP3 and MMP14 was observed when Akt inhibitor was applied both in vitro and in vivo. This study provides new insights into the role of CNTF on the migration of corneal epithelial stem/progenitor cells and its inherent mechanism of Up-regulation of matrix metalloproteinases through the Akt signalling pathway. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oftalmologi0 (SwePub)302172 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Ophthalmology0 (SwePub)302172 hsv//eng |
| 700 | 1 | a Chen, Peng4 aut |
| 700 | 1 | a Backman, Ludvig J.u Umeå universitet,Anatomi4 aut0 (Swepub:umu)lugban04 |
| 700 | 1 | a Zhou, Qingjun4 aut |
| 700 | 1 | a Danielson, Patriku Umeå universitet,Anatomi,Oftalmiatrik4 aut0 (Swepub:umu)pakdan00 |
| 710 | 2 | a Umeå universitetb Anatomi4 org |
| 773 | 0 | t Scientific Reportsd : Springer Science and Business Media LLCg 6q 6x 2045-2322 |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:941314/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.nature.com/articles/srep25870.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-121443 |
| 856 | 4 8 | u https://doi.org/10.1038/srep25870 |
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