onr:"swepub:oai:DiVA.org:umu-12876"
Sökning: onr:"swepub:oai:DiVA.org:umu-12876" > Serum antibody resp...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02950naa a2200361 4500 | |
| 001 | oai:DiVA.org:umu-12876 | |
| 003 | SwePub | |
| 008 | 071109s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128762 URI |
| 024 | 7 | a https://doi.org/10.1093/ije/dyl1662 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Vilkuna-Rautiainen, T4 aut |
| 245 | 1 0 | a Serum antibody response to periodontal pathogens and herpes simplex virus in relation to classic risk factors of cardiovascular disease. |
| 264 | c 2006-09-22 | |
| 264 | 1 | b Oxford University Press (OUP),c 2006 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: Increasing evidence links chronic infections, especially burden of several infections, with increased risk for cardiovascular diseases (CVD). We studied joint immune response against two major periodontal pathogens and herpes simplex virus (HSV) in relation to established risk factors of CVD. METHODS: Serum antibody levels to HSV, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were determined by ELISA. The study included 1107 subjects, 734 from Finland and 373 from Russia. RESULTS: Combined antibody response to periodontal pathogens was associated inversely (OR, 95% CI) with high-density lipoprotein (HDL) cholesterol concentration (beta = 0.35; 0.20, 0.60; P < 0.001) and directly with HSV antibody quartiles: compared with the first quartile, ORs (95% CI) for quartiles 2-4 were 1.43 (0.88-2.32), 1.74 (1.07-2.82), and 1.89 (1.18-3.02), respectively (P for trend <0.001), after adjusting for age, gender, area, education, smoking, BMI, alcohol, triglycerides, and number of teeth. In linear regression analysis, the 3-pathogen antibody score (comprising antibody levels against periodontal pathogens and HSV) was inversely associated with HDL cholesterol concentration (beta = -0.067/1 mmol/l; -0.235, -0.018; P < 0.05). CONCLUSIONS: HSV infection may promote infection by periodontal pathogens. Furthermore, the infectious burden comprising HSV and periodontitis may increase the risk for CVD by clearly decreasing HDL cholesterol concentrations. | |
| 700 | 1 | a Pussinen, PJ4 aut |
| 700 | 1 | a Roivainen, M4 aut |
| 700 | 1 | a Petäys, T4 aut |
| 700 | 1 | a Jousilahti, P4 aut |
| 700 | 1 | a Hovi, T4 aut |
| 700 | 1 | a Vartiainen, E4 aut |
| 700 | 1 | a Asikainen, Sirkkau Umeå universitet,Oral mikrobiologi4 aut0 (Swepub:umu)sias0001 |
| 710 | 2 | a Umeå universitetb Oral mikrobiologi4 org |
| 773 | 0 | t International Journal of Epidemiologyd : Oxford University Press (OUP)g 35:6, s. 1486-1494q 35:6<1486-1494x 0300-5771x 1464-3685 |
| 856 | 4 | u https://academic.oup.com/ije/article-pdf/35/6/1486/1878279/dyl166.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-12876 |
| 856 | 4 8 | u https://doi.org/10.1093/ije/dyl166 |
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