SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-135264"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-135264" > Clinical markers of...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006714naa a2200721 4500
001oai:DiVA.org:umu-135264
003SwePub
008170526s2017 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-322681
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1352642 URI
0247 a https://doi.org/10.1111/cea.129062 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3226812 URI
040 a (SwePub)umud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bertelsen, R. J.u Uppsala universitet,Lung- allergi- och sömnforskning,Tartu Univ Hosp, Lung Clin, Tartu, Estonia.4 aut
2451 0a Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring
264 c 2017-03-28
264 1b Wiley,c 2017
338 a electronic2 rdacarrier
520 a Background: Mice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans.Objective: We aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness (BHR), and total and specific IgEs, measured before conception vs. after birth, with offspring asthma and hayfever.Methods: The study included 4293 participants (mean age 34, 47% men) from the European Community Respiratory Health Survey (ECRHS) with information on asthma symptom severity, BHR, total and specific IgEs from 1991 to 1993, and data on 9100 offspring born 1972–2012. Adjusted relative risk ratios (aRRR) for associations of parental clinical outcome with offspring allergic disease were estimated with multinomial logistic regressions.Results: Offspring asthma with hayfever was more strongly associated with parental BHR and specific IgE measured before conception than after birth [BHR: aRRR = 2.96 (95% CI: 1.92, 4.57) and 1.40 (1.03, 1.91), respectively; specific IgEs: 3.08 (2.13, 4.45) and 1.83 (1.45, 2.31), respectively]. This was confirmed in a sensitivity analysis of a subgroup of offspring aged 11–22 years with information on parental disease activity both before and after birth.Conclusion & Clinical Relevance: Parental BHR and specific IgE were associated with offspring asthma and hayfever, with the strongest associations observed with clinical assessment before conception as compared to after birth of the child. If the hypothesis is confirmed in other studies, parental disease activity assessed before conception may prove useful for identifying children at risk for developing asthma with hayfever.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a asthma
653 a clinical immunology
653 a European Community Respiratory Health Survey
653 a epidemiology
653 a IgE
653 a fspring
653 a preconception
653 a rhinitis
7001 a Rava, M.u INSERM U1168, VIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Villejuif, France.;Univ Versailles St Quentin En Yvelines, UMR S 1168, Montigny Le Bretonneux, France.;Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain.4 aut
7001 a Carsin, A. E.u Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBERESP, Barcelona, Spain.4 aut
7001 a Accordini, S.u Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy.4 aut
7001 a Benediktsdottir, B.u Univ Iceland, Fac Med, Reykjavik, Iceland.,INSERM, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Epidemiol Team, Paris, France.;Univ Paris Diderot Paris 7, UMR 1152, Paris, France.4 aut
7001 a Dratva, J.u Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.,Imperial Coll, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London, England.4 aut
7001 a Franklin, Karl A.u Umeå universitet,Kirurgi,Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden.4 aut0 (Swepub:umu)kafr0021
7001 a Heinrich, J.u Helmholtz Zentrum Munchen, Inst Epidemiol 1, German Res Ctr Environm Hlth, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.4 aut
7001 a Holm, M.u Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.4 aut
7001 a Janson, C.u Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)chrisjn
7001 a Johannessen, A.u Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Haukeland Hosp, Clin Res Ctr, Bergen, Norway.4 aut
7001 a Jarvis, D. L.4 aut
7001 a Jogi, R.u Univ Huelva, Dept Nursing, Huelva, Spain.4 aut
7001 a Leynaert, B.4 aut
7001 a Norback, D.u Uppsala universitet,Arbets- och miljömedicin4 aut0 (Swepub:uu)dagnorba
7001 a Omenaas, E. R.u Univ Bergen, Dept Clin Sci, POB 7804, N-5020 Bergen, Norway.;Haukeland Hosp, Clin Res Ctr, Bergen, Norway.4 aut
7001 a Raherison, C.u Bordeaux Univ, INSERM U897, Bordeaux, France.4 aut
7001 a Sanchez-Ramos, J. L.4 aut
7001 a Schlunssen, V.u Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Natl Res Ctr Working Environm, Copenhagen, Denmark.4 aut
7001 a Sigsgaard, T.u Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.4 aut
7001 a Dharmage, S. C.u Univ Melbourne, Melbourne Sch Populat Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.,Haukeland Hosp, Dept Occupat Med, Bergen, Norway.;Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.4 aut
7001 a Svanes, C.4 aut
7102 a Uppsala universitetb Lung- allergi- och sömnforskning4 org
7730 t Clinical and Experimental Allergyd : Wileyg 47:5, s. 627-638q 47:5<627-638x 0954-7894x 1365-2222
8564 u https://doi.org/10.1111/cea.12906y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1098817/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cea.12906
8564 u https://uu.diva-portal.org/smash/get/diva2:1099144/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-135264
8564 8u https://doi.org/10.1111/cea.12906
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-322681

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy