Sökning: onr:"swepub:oai:DiVA.org:umu-138032" >
Early pregnancy sex...
Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer : a nested case-control study in the Northern Sweden Maternity Cohort
-
Fortner, Renee T. (författare)
-
- Tolockiene, Egle (författare)
- Umeå universitet,Patologi
-
Schock, Helena (författare)
-
visa fler...
-
- Oda, Husam (författare)
- Umeå universitet,Patologi
-
- Lakso, Hans-Åke (författare)
- Umeå universitet,Klinisk kemi
-
- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning,Arcum
-
Kaaks, Rudolf (författare)
-
Toniolo, Paolo (författare)
-
Zeleniuch-Jacquotte, Anne (författare)
-
- Grankvist, Kjell (författare)
- Umeå universitet,Klinisk kemi
-
- Lundin, Eva (författare)
- Umeå universitet,Patologi
-
visa färre...
-
(creator_code:org_t)
- 2017-07-18
- 2017
- Engelska.
-
Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 19
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://breast-cance...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones.Methods: We conducted a nested case–control study in the Northern Sweden Maternity Cohort (1975–2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection). Estrogen receptor (ER) and progesterone receptor (PR) status was available for all cases; androgen receptor (AR) data were available for 41% of cases (n = 92). Sex steroids were quantified by high-performance liquid chromatography tandem mass spectrometry. Odds ratios (ORs) and 95% confidence intervals were estimated using conditional logistic regression.Results: Higher concentrations of circulating progesterone in early pregnancy were inversely associated with ER+/PR+ breast cancer risk (ORlog2: 0.64 (0.41–1.00)). Higher testosterone was positively associated with ER+/PR+ disease risk (ORlog2: 1.57 (1.13–2.18)). Early pregnancy estrogens were not associated with risk, except for relatively high estradiol in the context of low progesterone (split at median, relative to low concentrations of both; OR: 1.87 (1.11–3.16)). None of the investigated hormones were associated with ER–/PR– disease, or with AR+ or AR+/ER+/PR+ disease.Conclusions: Consistent with experimental models, high progesterone in early pregnancy was associated with lower risk of ER+/PR+ breast cancer in the mother. High circulating testosterone in early pregnancy, which likely reflects nonpregnant premenopausal exposure, was associated with higher risk of ER+/PR+ disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Endogenous hormones
- Early pregnancy
- Breast cancer
- Sex steroids
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Fortner, Renee T ...
-
Tolockiene, Egle
-
Schock, Helena
-
Oda, Husam
-
Lakso, Hans-Åke
-
Hallmans, Göran
-
visa fler...
-
Kaaks, Rudolf
-
Toniolo, Paolo
-
Zeleniuch-Jacquo ...
-
Grankvist, Kjell
-
Lundin, Eva
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reproduktionsmed ...
- Artiklar i publikationen
-
Breast Cancer Re ...
- Av lärosätet
-
Umeå universitet