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Sökning: onr:"swepub:oai:DiVA.org:umu-142377" > TAP1 down-regulatio...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003512naa a2200433 4500
001oai:DiVA.org:umu-142377
003SwePub
008171129s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1423772 URI
0247 a https://doi.org/10.1080/2162402X.2017.13561432 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ling, Agnes,d 1976-u Umeå universitet,Patologi4 aut0 (Swepub:umu)agslig01
2451 0a TAP1 down-regulation elicits immune escape and poor prognosis in colorectal cancer
264 1c 2017
338 a print2 rdacarrier
520 a The anti-tumor immune response has been shown to be of great prognostic importance in colorectal cancer (CRC) and so has the tumors ability for immune evasion. Our aim of this study was to investigate tumor factors that influence immunity. We used a gene expression array to search for potential mechanisms of tumor immune escape. One candidate gene identified was TAP1, involved in antigen presentation by MHC class I. TAP1 protein expression was evaluated by immunohistochemistry in 436 CRC patients of the Colorectal Cancer in Umeå Study cohort. We found a significant association between a downregulated expression of TAP1 and low infiltration of various subtypes of lymphocytes as well as macrophages. A downregulated expression of TAP1 was further found to be independent of molecular characteristics, suggesting TAP1 down-regulation to reach beyond the well described highly immunogenic MSI CRCs. A low expression of TAP1 was also significantly associated with poor prognosis in patients with CRC, a result that stayed significant in tumor front of early stage tumors (stage I-II) through multivariable analyses. Furthermore, we found that TAP1 expression was inversely correlated with methylation at sites in close proximity to the promoter region. In summary, our results show down-regulation of TAP1 to be a general mechanism of tumor immune escape in CRC and a poor prognostic factor in stage I-II CRC patients. We also suggest that methylation of the TAP1 gene may be a putative mechanism for TAP1 downregulation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a TAP1
653 a antigen presentation
653 a colorectal cancer
653 a immune escape
653 a prognosis
7001 a Löfgren-Burström, Annau Umeå universitet,Patologi4 aut0 (Swepub:umu)anlo0002
7001 a Larsson, Päru Umeå universitet,Patologi4 aut0 (Swepub:umu)pala0006
7001 a Li, Xingruu Umeå universitet,Patologi4 aut0 (Swepub:umu)xili0010
7001 a Wikberg, Maria Lu Umeå universitet,Patologi4 aut0 (Swepub:umu)mahe0061
7001 a Öberg, Åkeu Umeå universitet,Kirurgi4 aut
7001 a Stenling, Rogeru Umeå universitet,Patologi4 aut0 (Swepub:umu)rost0001
7001 a Edin, Sofiau Umeå universitet,Patologi4 aut0 (Swepub:umu)soed0001
7001 a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001
7102 a Umeå universitetb Patologi4 org
7730 t Oncoimmunologyg 6:11q 6:11x 2162-4011x 2162-402X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142377
8564 8u https://doi.org/10.1080/2162402X.2017.1356143

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