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Sökning: onr:"swepub:oai:DiVA.org:umu-145129" > Ovarian cancer earl...

  • Fortner, Renée T.German Cancer Research Centre (författare)

Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels : Results from the EPIC cohort

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2017-12-11
  • John Wiley & Sons,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-145129
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-145129URI
  • https://doi.org/10.1002/ijc.31164DOI
  • https://lup.lub.lu.se/record/011e0c84-baf3-43f0-961d-5e00b58414a2URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137615475URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases. We investigated these objectives using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to four matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2-year lag-time intervals were calculated using conditional logistic regression calibrated toward the absolute risk estimates from a pre-existing epidemiological risk model as an offset-variable. Anti-CA125 levels alone did not discriminate cases from controls. For cases diagnosed <2 years after blood collection, discrimination by CA125 antigen was suggestively higher with higher anti-CA125 levels (aAUC, highest antibody tertile: 0.84 [0.76-0.92]; lowest tertile: 0.76 [0.67-0.86]; p(het)=0.06). We provide the first evidence of potentially synergistic discrimination effects of CA125 and anti-CA125 antibodies in ovarian early detection. If these findings are replicated, evaluating CA125 in the context of its antibody may improve ovarian cancer early detection. What's new? Although CA125, a mucin produced in epithelial cells, is a known marker for ovarian cancer, complementary biomarkers are necessary for reliable early cancer detection. Here, the authors examined autoantibodies against CA125 as potential pre-diagnosis markers. Although anti-CA125 levels did not discriminate between ovarian cases and controls, discrimination of CA125 differed by levels of its antibody, with the highest discrimination among women with the highest antibody levels. The authors propose that CA125 and anti-CA125 may act synergistically for ovarian cancer early detection.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Schock, HelenaGerman Cancer Research Centre (författare)
  • Le Cornet, CharlotteGerman Cancer Research Centre (författare)
  • Hüsing, AnikaGerman Cancer Research Centre (författare)
  • Vitonis, Allison F.Brigham and Women's Hospital / Harvard Medical School (författare)
  • Johnson, Theron S.German Cancer Research Centre,Istituto Nazionale dei Tumori (författare)
  • Fichorova, Raina N.Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (författare)
  • Fashemi, TitilayoBrigham and Women's Hospital / Harvard Medical School (författare)
  • Yamamoto, Hidemi S.Brigham and Women's Hospital / Harvard Medical School (författare)
  • Tjonneland, AnneDanish Cancer Society (författare)
  • Hansen, LouiseDanish Cancer Society (författare)
  • Overvad, KimAarhus University (författare)
  • Boutron-Ruault, Marie-ChristineStabilite genetique et oncogenese,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP) (författare)
  • Kvaskoff, MarinaStabilite genetique et oncogenese,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP) (författare)
  • Severi, GianlucaCentre for Research in Epidemiology and Population Health (CESP),Human Genetics Foundation (HuGeF),University of Paris-Saclay,Stabilite genetique et oncogenese (författare)
  • Boeing, HeinerGerman Institute of Human Nutrition (författare)
  • Trichopoulou, AntoniaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens (författare)
  • Papatesta, Eleni-MariaHellenic Health Foundation, Athens (författare)
  • La Vecchia, CarloHellenic Health Foundation, Athens,University of Milan (författare)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (författare)
  • Sieri, Sabina (författare)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (författare)
  • Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin (författare)
  • Mattiello, AmaliaUniversity of Naples Federico II (författare)
  • Onland-Moret, N. CharlotteUniversity Medical Center Utrecht (författare)
  • Peeters, Petra H.University Medical Center Utrecht,Imperial College London (författare)
  • Bueno-de-Mesquita, H. B(as)National Institute for Public Health and the Environment (RIVM),Imperial College London (författare)
  • Weiderpass, ElisabeteKarolinska Institutet,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Folkhälsan Research Center (författare)
  • Quirós, J. RamónPublic Health Directorate (författare)
  • Duell, Eric J.Catalan Institute of Oncology (författare)
  • Sánchez, Maria-JoseUniversity of Granada,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Navarro, CarmenMurcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)(Swepub:lu)extLU-05 (författare)
  • Larrañaga, NereaPublic Health Division of Gipuzkoa,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Nodin, BjörnLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)immu-bnn (författare)
  • Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji (författare)
  • Idahl, AnnikaUmeå University,Umeå universitet,Obstetrik och gynekologi,Näringsforskning(Swepub:umu)anid0002 (författare)
  • Lundin, EvaUmeå University,Umeå universitet,Patologi(Swepub:umu)evlu0001 (författare)
  • Khaw, Kay-TeeUniversity of Cambridge (författare)
  • Travis, Ruth C.University of Oxford (författare)
  • Gunter, MarcInternational Agency for Research on Cancer, World Health Organization (författare)
  • Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization (författare)
  • Dossus, LaureInternational Agency for Research on Cancer, World Health Organization (författare)
  • Merritt, Melissa A.Imperial College London (författare)
  • Riboli, ElioImperial College London (författare)
  • Terry, Kathryn L.Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School (författare)
  • Cramer, Daniel W.Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School (författare)
  • Kaaks, RudolfGerman Cancer Research Centre (författare)
  • German Cancer Research CentreBrigham and Women's Hospital / Harvard Medical School (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Cancer: John Wiley & Sons142:7, s. 1355-13600020-71361097-0215

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