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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04694naa a2200553 4500 | |
| 001 | oai:DiVA.org:umu-147466 | |
| 003 | SwePub | |
| 008 | 180528s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1474662 URI |
| 024 | 7 | a https://doi.org/10.1002/term.26422 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jones, Iwanu Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)iwjo0002 |
| 245 | 1 0 | a Regenerative effects of human embryonic stem cell-derived neural crest cells for treatment of peripheral nerve injury |
| 264 | c 2018-02-18 | |
| 264 | 1 | b Hindawi Limited,c 2018 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Surgical intervention is the current gold standard treatment following peripheral nerve injury. However, this approach has limitations, and full recovery of both motor and sensory modalities often remains incomplete. The development of artificial nerve grafts that either complement or replace current surgical procedures is therefore of paramount importance. An essential component of artificial grafts is biodegradable conduits and transplanted cells that provide trophic support during the regenerative process. Neural crest cells are promising support cell candidates because they are the parent population to many peripheral nervous system lineages. In this study, neural crest cells were differentiated from human embryonic stem cells. The differentiated cells exhibited typical stellate morphology and protein expression signatures that were comparable with native neural crest. Conditioned media harvested from the differentiated cells contained a range of biologically active trophic factors and was able to stimulate in vitro neurite outgrowth. Differentiated neural crest cells were seeded into a biodegradable nerve conduit, and their regeneration potential was assessed in a rat sciatic nerve injury model. A robust regeneration front was observed across the entire width of the conduit seeded with the differentiated neural crest cells. Moreover, the up-regulation of several regeneration-related genes was observed within the dorsal root ganglion and spinal cord segments harvested from transplanted animals. Our results demonstrate that the differentiated neural crest cells are biologically active and provide trophic support to stimulate peripheral nerve regeneration. Differentiated neural crest cells are therefore promising supporting cell candidates to aid in peripheral nerve repair. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a artificial nerve graft | |
| 653 | a human embryonic stem cells | |
| 653 | a neural crest cells | |
| 653 | a peripheral nerve injuries | |
| 653 | a ripheral nervous system | |
| 653 | a VELOPMENTAL EVOLUTION | |
| 653 | a V314B | |
| 653 | a P95 e Gabsang | |
| 653 | a 2007 | |
| 653 | a NATURE BIOTECHNOLOGY | |
| 653 | a V25 | |
| 653 | a P1468 | |
| 700 | 1 | a Novikova, Liudmila N.u Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)luno0001 |
| 700 | 1 | a Novikov, Lev N.u Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)leno0001 |
| 700 | 1 | a Renardy, Monika4 aut |
| 700 | 1 | a Ullrich, Andreas4 aut |
| 700 | 1 | a Wiberg, Mikaelu Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Institutionen för kirurgisk och perioperativ vetenskap4 aut0 (Swepub:umu)miwi0004 |
| 700 | 1 | a Carlsson, Leifu Umeå universitet,Umeå centrum för molekylär medicin (UCMM)4 aut0 (Swepub:umu)leca0002 |
| 700 | 1 | a Kingham, Paul J.u Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)paki0006 |
| 710 | 2 | a Umeå universitetb Umeå centrum för molekylär medicin (UCMM)4 org |
| 773 | 0 | t Journal of Tissue Engineering and Regenerative Medicined : Hindawi Limitedg 12:4, s. E2099-E2109q 12:4<E2099-E2109x 1932-6254x 1932-7005 |
| 856 | 4 | u https://doi.org/10.1002/term.2642y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1210267/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/term.2642 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-147466 |
| 856 | 4 8 | u https://doi.org/10.1002/term.2642 |
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