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A heterogeneous res...
A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes : a randomised controlled trial
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- Otten, Julia, 1973- (författare)
- Umeå universitet,Medicin
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- Stomby, Andreas (författare)
- Umeå universitet,Medicin
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- Waling, Maria (författare)
- Umeå universitet,Institutionen för kostvetenskap
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- Isaksson, Andreas (författare)
- Umeå universitet,Idrottsmedicin
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- Söderström, Ingegerd (författare)
- Umeå universitet,Medicin
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- Ryberg, Mats (författare)
- Umeå universitet,Medicin
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- Svensson, Michael (författare)
- Umeå universitet,Idrottsmedicin
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- Hauksson, Jón (författare)
- Umeå universitet,Radiofysik
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- Olsson, Tommy (författare)
- Umeå universitet,Medicin
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(creator_code:org_t)
- 2018-04-26
- 2018
- Engelska.
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Ingår i: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 61:7, s. 1548-1559
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Aims/hypothesis: The aim of the study was to investigate ectopic fat deposition and insulin sensitivity, in a parallel single-blinded randomised controlled trial, comparing Paleolithic diet alone with the combination of Paleolithic diet and exercise in individuals with type 2 diabetes. Methods: Thirty-two individuals with type 2 diabetes with BMI 25-40 kg/m(2) and 30-70 years of age followed a Paleolithic diet ad libitum for 12 weeks. In addition, study participants were randomised by computer program to either supervised combined exercise training (PD-EX group) or standard care exercise recommendations (PD group). Staff performing examinations and assessing outcomes were blinded to group assignment. Thirteen participants were analysed in each group: hepatic and peripheral insulin sensitivity were measured using the hyperinsulinaemic-euglycaemic clamp technique combined with [6,6-H-2(2)]glucose infusion, and liver fat was assessed by proton magnetic resonance spectroscopy; both analyses were secondary endpoints. Intramyocellular lipid (IMCL) content was measured by magnetic resonance spectroscopy as a secondary analysis. All examinations were performed at Umca University Hospital, Umca, Sweden. Results: Both study groups showed a median body weight loss of 7 kg. Fat mass decreased by 5.7 kg in the PD group and by 6.5 kg in the PD-EX group. Maximum oxygen uptake increased in the PD-EX group only. Liver fat showed a consistent reduction (74% decrease) in the PD group, while the response in the PD-EX group was heterogeneous (p < 0.05 for the difference between groups). IMCL content of the soleus muscle decreased by 40% in the PD group and by 22% in the PD-EX group (p < 0.05 for the difference between groups). Both groups improved their peripheral and adipose tissue insulin sensitivity, but not their hepatic insulin sensitivity. Plasma fetuin-A decreased by 11% in the PD group (p < 0.05) and remained unchanged in the PD-EX group. Liver fat changes during the intervention were correlated with changes in fetuin-A (r(S) = 0.63, p < 0.01). Participants did not report any important adverse events caused by the intervention. Conclusions/interpretation: A Paleolithic diet reduced liver fat and IMCL content, while there was a tissue-specific heterogeneous response to added exercise training.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Exercise
- Hyperinsulinaemic-euglycaemic clamp
- Insulin sensitivity
- Intramyocellular fat
- Liver fat
- Nutrition
- Obesity
- Paleolithic diet
- Proton magnetic resonance spectroscopy
- Weight loss
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Otten, Julia, 19 ...
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Stomby, Andreas
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Waling, Maria
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Isaksson, Andrea ...
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Söderström, Inge ...
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Ryberg, Mats
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Svensson, Michae ...
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Hauksson, Jón
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Olsson, Tommy
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- MEDICIN OCH HÄLSOVETENSKAP
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Diabetologia
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Umeå universitet