onr:"swepub:oai:DiVA.org:umu-150784"
Sökning: onr:"swepub:oai:DiVA.org:umu-150784" > Exposure to an anti...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04861naa a2200541 4500 | |
| 001 | oai:DiVA.org:umu-150784 | |
| 003 | SwePub | |
| 008 | 180816s2018 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-358521 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1507842 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-018-27161-22 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3585212 URI |
| 040 | a (SwePub)umud (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Orton, F.u Univ West Scotland, Sch Sci & Sport, Paisley, Renfrew, Scotland4 aut |
| 245 | 1 0 | a Exposure to an anti-androgenic herbicide negatively impacts reproductive physiology and fertility in Xenopustropicalis |
| 264 | c 2018-06-14 | |
| 264 | 1 | b Nature Publishing Group,c 2018 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Amphibians are threatened on a global scale and pollutants may be contributing to population declines, but how chemicals impact on their reproduction is poorly understood. We conducted a life cycle analysis to investigate the impacts of early life exposure to two anti-androgens (exposure until completion of metamorphosis;stage 66): flutamide, (50 µg/L)/linuron (9 and 45 µg/L)) on sexual development and breeding competence in Xenopus tropicalis. Our analyses included: mRNA levels of dmrt1, cyp17, amh, cyp19, foxl2 and ar (tadpoles/metamorphs), gonadal histomorphology (metamorphs/adults), mRNA levels of ar/gr (adult male brain/gonad/forelimb), testosterone/corticosterone levels (adult males), secondary sexual characteristics (forelimb width/nuptial pad: adult males) and breeding competence (amplexus/fertility: adult males). Compared to controls, feminised sex ratios and increased number of spermatogonia (adults) were observed after exposure to flutamide and the lower linuron concentration. Exposure to the lower linuron concentration also resulted in demasculinisation of secondary sexual characteristics and reduced male fertility. Flutamide exposure resulted in masculinisation of the nuptial pad and elevated mRNA levels of dmrt1, cyp17, amh and foxl2 in brains (metamorphs). Testosterone levels were higher in all treatment groups, however, overall few effects were observed in response to the higher linuron concentration. Our findings advance understanding of reproductive biology of X. tropicalis and illustrate negative effects of linuron on reproductive processes at a concentration measured in freshwater environments. | |
| 650 | 7 | a NATURVETENSKAPx Geovetenskap och miljövetenskapx Miljövetenskap0 (SwePub)105022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Earth and Related Environmental Sciencesx Environmental Sciences0 (SwePub)105022 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Ekologi0 (SwePub)106112 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Ecology0 (SwePub)106112 hsv//eng |
| 700 | 1 | a Säfholm, Moau Uppsala universitet,Miljötoxikologi4 aut0 (Swepub:uu)moakv992 |
| 700 | 1 | a Jansson, Erikau Uppsala universitet,Miljötoxikologi4 aut0 (Swepub:uu)erija909 |
| 700 | 1 | a Carlsson, Y.u Uppsala universitet,Miljötoxikologi4 aut |
| 700 | 1 | a Eriksson, A.u Uppsala universitet,Miljötoxikologi4 aut |
| 700 | 1 | a Fick, Jerkeru Umeå universitet,Kemiska institutionen,Umea Univ, Dept Chem, Umea, Sweden4 aut0 (Swepub:umu)jefi0001 |
| 700 | 1 | a Webster, T. Urenu Swansea Univ, Swansea, W Glam, Wales4 aut |
| 700 | 1 | a McMillan, T.u Univ West Scotland, Sch Sci & Sport, Paisley, Renfrew, Scotland4 aut |
| 700 | 1 | a Leishman, M.u Univ West Scotland, Sch Sci & Sport, Paisley, Renfrew, Scotland4 aut |
| 700 | 1 | a Verbruggen, B.u Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England4 aut |
| 700 | 1 | a Economou, T.u Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England4 aut |
| 700 | 1 | a Tyler, C. R.u Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England4 aut |
| 700 | 1 | a Berg, Cecilia,d 1967-u Uppsala universitet,Miljötoxikologi4 aut0 (Swepub:uu)ceciberg |
| 710 | 2 | a Univ West Scotland, Sch Sci & Sport, Paisley, Renfrew, Scotlandb Miljötoxikologi4 org |
| 773 | 0 | t Scientific Reportsd : Nature Publishing Groupg 8q 8x 2045-2322 |
| 856 | 4 | u https://doi.org/10.1038/s41598-018-27161-2y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1239393/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.nature.com/articles/s41598-018-27161-2.pdf |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1244656/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150784 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-018-27161-2 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-358521 |
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