onr:"swepub:oai:DiVA.org:umu-16706"
Sökning: onr:"swepub:oai:DiVA.org:umu-16706" > The novel ETS facto...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02994naa a2200589 4500 | |
| 001 | oai:DiVA.org:umu-16706 | |
| 003 | SwePub | |
| 008 | 071009s2005 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167062 URI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Cardone, Monica4 aut |
| 245 | 1 0 | a The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis. |
| 264 | 1 | c 2005 |
| 338 | a print2 rdacarrier | |
| 520 | a The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and MYC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies. | |
| 653 | a Animals | |
| 653 | a Apoptosis | |
| 653 | a B-Lymphocytes/metabolism | |
| 653 | a Burkitt Lymphoma/genetics/*metabolism | |
| 653 | a Cell Proliferation | |
| 653 | a Child | |
| 653 | a DNA-Binding Proteins/genetics/*metabolism | |
| 653 | a Female | |
| 653 | a Humans | |
| 653 | a Leukemia; B-Cell; Acute/genetics/*metabolism | |
| 653 | a Male | |
| 653 | a Mice | |
| 653 | a Mice; Transgenic | |
| 653 | a Mutation/genetics | |
| 653 | a Proto-Oncogene Proteins c-ets | |
| 653 | a Proto-Oncogene Proteins c-myc/*metabolism | |
| 653 | a Suppression; Genetic | |
| 653 | a Transcription Factors/genetics/*metabolism | |
| 653 | a Tumor Suppressor Protein p53/genetics | |
| 653 | a Up-Regulation/genetics | |
| 700 | 1 | a Kandilci, Ayten4 aut |
| 700 | 1 | a Carella, Cintia4 aut |
| 700 | 1 | a Nilsson, Jonas Au Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 aut |
| 700 | 1 | a Brennan, Jennifer A4 aut |
| 700 | 1 | a Sirma, Sema4 aut |
| 700 | 1 | a Ozbek, Ugur4 aut |
| 700 | 1 | a Boyd, Kelli4 aut |
| 700 | 1 | a Cleveland, John L4 aut |
| 700 | 1 | a Grosveld, Gerard C4 aut |
| 710 | 2 | a Umeå universitetb Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 org |
| 773 | 0 | t Mol Cell Biolg 25:6, s. 2395-405q 25:6<2395-405x 0270-7306 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15743832&dopt=Citation |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16706 |
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Cardone, Monica
- Kandilci, Ayten
- Carella, Cintia
- Nilsson, Jonas A
- Brennan, Jennife ...
- Sirma, Sema
- visa fler...
- Ozbek, Ugur
- Boyd, Kelli
- Cleveland, John ...
- Grosveld, Gerard ...
- visa färre...
- Artiklar i publikationen
- Mol Cell Biol
- Av lärosätet
- Umeå universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
