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A single-nucleotide...
A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity
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Akkaya, Munir (author)
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Bansal, Abhisheka (author)
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Sheehan, Patrick W. (author)
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Pena, Mirna (author)
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Molina-Cruz, Alvaro (author)
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Orchard, Lindsey M. (author)
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Cimperman, Clare K. (author)
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Qi, Chen-Feng (author)
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Ross, Philipp (author)
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Yazew, Takele (author)
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Sturdevant, Daniel (author)
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Anzick, Sarah L. (author)
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Thiruvengadam, Girija (author)
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Otto, Thomas Dan (author)
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- Billker, Oliver (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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Llinas, Manuel (author)
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Miller, Louis H. (author)
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Pierce, Susan K. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science, 2020
- 2020
- English.
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In: Science Advances. - : American Association for the Advancement of Science. - 2375-2548. ; 6:6
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host's ability to mount a protective immune response. Here, we show that a single-nucleotide polymorphism (SNP) resulting in a single amino acid change (S to F) in an ApiAP2 transcription factor in the rodent malaria parasite Plasmodium berghei (Pb) NK65 allowed infected mice to mount a T helper cell 1 (T(H)1)-type immune response that controlled subsequent infections. As compared to PbNK65(S), PbNK65(F) parasites differentially expressed 46 genes, most of which are predicted to play roles in immune evasion. PbNK65(F) infections resulted in an early interferon-gamma response and a later expansion of germinal centers, resulting in high levels of infected red blood cell-specific T(H)1-type immunoglobulin G2b (IgG2b) and IgG2c antibodies. Thus, the Pb ApiAP2 transcription factor functions as a critical parasite virulence factor in malaria infections.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Akkaya, Munir
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Bansal, Abhishek ...
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Sheehan, Patrick ...
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Pena, Mirna
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Molina-Cruz, Alv ...
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Orchard, Lindsey ...
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show more...
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Cimperman, Clare ...
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Qi, Chen-Feng
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Ross, Philipp
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Yazew, Takele
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Sturdevant, Dani ...
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Anzick, Sarah L.
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Thiruvengadam, G ...
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Otto, Thomas Dan
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Billker, Oliver
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Llinas, Manuel
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Miller, Louis H.
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Pierce, Susan K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Science Advances
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Umeå University