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Sökning: onr:"swepub:oai:DiVA.org:umu-170024" > The prognostic role...

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FältnamnIndikatorerMetadata
00004849naa a2200457 4500
001oai:DiVA.org:umu-170024
003SwePub
008200505s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-81339
009oai:prod.swepub.kib.ki.se:143428049
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1700242 URI
0247 a https://doi.org/10.1136/ijgc-2019-ESGO.6662 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-813392 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1434280492 URI
040 a (SwePub)umud (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Razumova, Z.u Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden4 aut
2451 0a The prognostic role of LRIG proteins in endometrial cancer
264 1b BMJ Publishing Group Ltd,c 2019
338 a print2 rdacarrier
500 a Supplement: 4Meeting Abstract: EP609
520 a Introduction/Background Endometrial cancer (EC) is the most common gynaecological malignancy in Sweden. The disease has several prognostic factors. Still, the high amount of EC develops into more aggressive forms of cancer, even though being first considered to be non-aggressive. The LRIG proteins are a family of three integral surface proteins that have a similar domain organisation. The current study evaluated the role of LRIG proteins as prognostic biomarkers in EC.Methodology The cohort included 75 women who underwent a hysterectomy and bilateral salpingo-oophorectomydue to EC at the Department of Women's and Children's Health, Karolinska University Hospital Solna between 2007 and 2012. The expression of LRIG1, LRIG2, and LRIG3 in paraffin biopsies was analysed by immunohistochemistry (IHC) with applying specific polyclonal antibodies. Evaluation of immunostainings was performed by two senior pathologists without knowledge of the disease outcome. The percentage of positive cells was divided in two groups with median percentage as cut off to have two groups of equal size included in the statistical analysis. Then the groups were assessedin connection with different tumour characteristics and clinical outcomes of EC.Results The majority of women in the cohort had >50% LRIG1-, LRIG2-, and LRIG3-positive cells. Among 6047 person-months of follow-up a total, of 14 incident cases of relapsed EC were identified. A statistically significant association between high LRIG3 expression and superior overall survival was observed in the cohort (IRR=2.559, 95 CI=1.054–6.210, p=0.038). LRIG1 and LRIG2 expression did not significantly correlate with survival.Conclusion Our results support the hypothesis that LRIG3 expression may have a prognostic role in women with EC. The significance of LRIG1 and LRIG2 expression remains to be clarified.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
7001 a Oda, H.u Department of Medical Biosciences, Umeå University, Umeå, Sweden4 aut
7001 a Govorov, I.u Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Lundin, E.u Department of Medical Biosciences, Umeå University, Umeå, Sweden4 aut
7001 a Östensson, E.u Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Lindquist, Davidu Umeå universitet,Onkologi,Department of Radiation Sciences, Umeå University, Umeå, Sweden4 aut0 (Swepub:umu)dali0066
7001 a Mints, Miriam,d 1958-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)mms
7102 a Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Swedenb Department of Medical Biosciences, Umeå University, Umeå, Sweden4 org
7730 t International Journal of Gynecological Cancerd : BMJ Publishing Group Ltdg 29, s. A358-A358q 29<A358-A358x 1048-891Xx 1525-1438
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170024
8564 8u https://doi.org/10.1136/ijgc-2019-ESGO.666
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81339
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143428049

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