A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer

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Fältnamn	Indikatorer	Metadata
000		06822naa a2201429 4500
001		oai:DiVA.org:umu-179656
003		SwePub
008		210205s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1796562 URI
024	7	a https://doi.org/10.1093/jnci/djz2462 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Zhong, Jun4 aut
245	1 0	a A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer
264		c 2020-04-05
264	1	b Oxford University Press,c 2020
338		a print2 rdacarrier
520		a Background: Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. Methods: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. We integrated genome-wide association studies summary statistics from 9040 pancreatic cancer cases and 12 496 controls, with gene expression prediction models built using transcriptome data from histologically normal pancreatic tissue samples (NCI Laboratory of Translational Genomics [n = 95] and Genotype-Tissue Expression v7 [n = 174] datasets) and data from 48 different tissues (Genotype-Tissue Expression v7, n = 74-421 samples). Results: We identified 25 genes whose genetically predicted expression was statistically significantly associated with pancreatic cancer risk (false discovery rate < .05), including 14 candidate genes at 11 novel loci (1p36.12: CELA3B; 9q31.1: SMC2, SMC2-AS1; 10q23.31: RP11-80H5.9; 12q13.13: SMUG1; 14q32.33: BTBD6; 15q23: HEXA; 15q26.1: RCCD1; 17q12: PNMT, CDK12, PGAP3; 17q22: SUPT4H1; 18q11.22: RP11-888D10.3; and 19p13.11: PGPEPI) and 11 at six known risk loci (5p15.33: TERT, CLPTMIL, ZDHHCIIB; 7p14.1: INHBA; 9q34.2: ABO; 13q12.2: PDX1; 13q22.1: KLF5; and 16q23.1: WDR59, CFDP1, BCAR1, TMEM170A). The association for 12 of these genes (CELA3B, SMC2, and PNMT at novel risk loci and TERT, CLPTMIL, INHBA, ABO, PDX1, KLF5, WDR59, CFDP1, and BCAR1 at known loci) remained statistically significant after Bonferroni correction. Conclusions: By integrating gene expression and genotype data, we identified novel pancreatic cancer risk loci and candidate functional genes that warrant further investigation.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Jermusyk, Ashley4 aut
700	1	a Wu, Lang4 aut
700	1	a Hoskins, Jason W.4 aut
700	1	a Collins, Irene4 aut
700	1	a Mocci, Evelina4 aut
700	1	a Zhang, Mingfeng4 aut
700	1	a Song, Lei4 aut
700	1	a Chung, Charles C.4 aut
700	1	a Zhang, Tongwu4 aut
700	1	a Xiao, Wenming4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Andreotti, Gabriella4 aut
700	1	a Arslan, Alan A.4 aut
700	1	a Babic, Ana4 aut
700	1	a Bamlet, William R.4 aut
700	1	a Beane-Freeman, Laura4 aut
700	1	a Berndt, Sonja4 aut
700	1	a Borgida, Ayelet4 aut
700	1	a Bracci, Paige M.4 aut
700	1	a Brais, Lauren4 aut
700	1	a Brennan, Paul4 aut
700	1	a Bueno-de-Mesquita, Bas4 aut
700	1	a Buring, Julie4 aut
700	1	a Canzian, Federico4 aut
700	1	a Childs, Erica J.4 aut
700	1	a Cotterchio, Michelle4 aut
700	1	a Du, Mengmeng4 aut
700	1	a Duell, Eric J.4 aut
700	1	a Fuchs, Charles4 aut
700	1	a Gallinger, Steven4 aut
700	1	a Gaziano, J. Michael4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Giovannucci, Edward4 aut
700	1	a Goggins, Michael4 aut
700	1	a Goodman, Gary E.4 aut
700	1	a Goodman, Phyllis J.4 aut
700	1	a Haiman, Christopher4 aut
700	1	a Hartge, Patricia4 aut
700	1	a Hasan, Manal4 aut
700	1	a Helzlsouer, Kathy J.4 aut
700	1	a Holly, Elizabeth A.4 aut
700	1	a Klein, Eric A.4 aut
700	1	a Kogevinas, Manolis4 aut
700	1	a Kurtz, Robert J.4 aut
700	1	a LeMarchand, Loic4 aut
700	1	a Malats, Nuria4 aut
700	1	a Mannisto, Satu4 aut
700	1	a Milne, Roger4 aut
700	1	a Neale, Rachel E.4 aut
700	1	a Ng, Kimmie4 aut
700	1	a Obazee, Ofure4 aut
700	1	a Oberg, Ann L.4 aut
700	1	a Orlow, Irene4 aut
700	1	a Patel, Alpa, V4 aut
700	1	a Peters, Ulrike4 aut
700	1	a Porta, Miquel4 aut
700	1	a Rothman, Nathaniel4 aut
700	1	a Scelo, Ghislaine4 aut
700	1	a Sesso, Howard D.4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Sieri, Sabina4 aut
700	1	a Silverman, Debra4 aut
700	1	a Sund, Malinu Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021
700	1	a Tjonneland, Anne4 aut
700	1	a Thornquist, Mark D.4 aut
700	1	a Tobias, Geoffrey S.4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Van den Eeden, Stephen K.4 aut
700	1	a Visvanathan, Kala4 aut
700	1	a Wactawski-Wende, Jean4 aut
700	1	a Wentzensen, Nicolas4 aut
700	1	a White, Emily4 aut
700	1	a Yu, Herbert4 aut
700	1	a Yuan, Chen4 aut
700	1	a Zeleniuch-Jacquotte, Anne4 aut
700	1	a Hoover, Robert4 aut
700	1	a Brown, Kevin4 aut
700	1	a Kooperberg, Charles4 aut
700	1	a Risch, Harvey A.4 aut
700	1	a Jacobs, Eric J.4 aut
700	1	a Li, Donghui4 aut
700	1	a Yu, Kai4 aut
700	1	a Shu, Xiao-Ou4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Wolpin, Brian M.4 aut
700	1	a Stolzenberg-Solomon, Rachael Z.4 aut
700	1	a Chatterjee, Nilanjan4 aut
700	1	a Klein, Alison P.4 aut
700	1	a Smith, Jill P.4 aut
700	1	a Kraft, Peter4 aut
700	1	a Shi, Jianxin4 aut
700	1	a Petersen, Gloria M.4 aut
700	1	a Zheng, Wei4 aut
700	1	a Amundadottir, Laufey T.4 aut
710	2	a Umeå universitetb Kirurgi4 org
773	0	t Journal of the National Cancer Instituted : Oxford University Pressg 112:10q 112:10x 0027-8874x 1460-2105
856	4	u https://academic.oup.com/jnci/article-pdf/112/10/1003/33879497/djz246.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179656
856	4 8	u https://doi.org/10.1093/jnci/djz246

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Av författaren/redakt...: Zhong, Jun; Jermusyk, Ashley; Wu, Lang; Hoskins, Jason W ...; Collins, Irene; Mocci, Evelina; visa fler...; Zhang, Mingfeng; Song, Lei; Chung, Charles C ...; Zhang, Tongwu; Xiao, Wenming; Albanes, Demetri ...; Andreotti, Gabri ...; Arslan, Alan A.; Babic, Ana; Bamlet, William ...; Beane-Freeman, L ...; Berndt, Sonja; Borgida, Ayelet; Bracci, Paige M.; Brais, Lauren; Brennan, Paul; Bueno-de-Mesquit ...; Buring, Julie; Canzian, Federic ...; Childs, Erica J.; Cotterchio, Mich ...; Du, Mengmeng; Duell, Eric J.; Fuchs, Charles; Gallinger, Steve ...; Gaziano, J. Mich ...; Giles, Graham G.; Giovannucci, Edw ...; Goggins, Michael; Goodman, Gary E.; Goodman, Phyllis ...; Haiman, Christop ...; Hartge, Patricia; Hasan, Manal; Helzlsouer, Kath ...; Holly, Elizabeth ...; Klein, Eric A.; Kogevinas, Manol ...; Kurtz, Robert J.; LeMarchand, Loic; Malats, Nuria; Mannisto, Satu; Milne, Roger; Neale, Rachel E.; Ng, Kimmie; Obazee, Ofure; Oberg, Ann L.; Orlow, Irene; Patel, Alpa, V; Peters, Ulrike; Porta, Miquel; Rothman, Nathani ...; Scelo, Ghislaine; Sesso, Howard D.; Severi, Gianluca; Sieri, Sabina; Silverman, Debra; Sund, Malin; Tjonneland, Anne; Thornquist, Mark ...; Tobias, Geoffrey ...; Trichopoulou, An ...; Van den Eeden, S ...; Visvanathan, Kal ...; Wactawski-Wende, ...; Wentzensen, Nico ...; White, Emily; Yu, Herbert; Yuan, Chen; Zeleniuch-Jacquo ...; Hoover, Robert; Brown, Kevin; Kooperberg, Char ...; Risch, Harvey A.; Jacobs, Eric J.; Li, Donghui; Yu, Kai; Shu, Xiao-Ou; Chanock, Stephen ...; Wolpin, Brian M.; Stolzenberg-Solo ...; Chatterjee, Nila ...; Klein, Alison P.; Smith, Jill P.; Kraft, Peter; Shi, Jianxin; Petersen, Gloria ...; Zheng, Wei; Amundadottir, La ...; visa färre...

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